| Reactivity | HuSpecies Glossary |
| Applications | Flow |
| Clone | 245106 |
| Clonality | Monoclonal |
| Host | Rat |
| Conjugate | Allophycocyanin |
| Immunogen | NS0 mouse myeloma cell line transfected with human HM74A/PUMA-G/GPR109A Met1-Pro363 Accession # Q8TDS4 |
| Specificity | Detects human HM74A/PUMA-G/GPR109A. Stains human HM74A/PUMA-G/GPR109A-transfected cells but not irrelevant transfectants. Cross-reactivity with HM74 (GPR109B) was not tested. |
| Source | N/A |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Host | Rat |
| Gene | HCAR2 |
| Purity Statement | Protein A or G purified from hybridoma culture supernatant |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Storage | Protect from light. Do not freeze.
|
| Buffer | Supplied in a saline solution containing BSA and Sodium Azide. |
| Preservative | Sodium Azide |
HM74A/GPR109A (also known as PUMA-G in mouse) is a 50-55 kDa 7-transmembrane protein member of a small subfamily within the GPCR #1 family. It is expressed on or in a wide variety of cells, including microglia, neutrophils, islet beta -cells, macrophages, adipocytes, retinal pigment epithelium and keratinocytes. Although HM74A is noted for its ability to bind niacin, it natural ligand is beta -hydroxybutyrate. Thus it may naturally act as a negative regulator of fatty acid release by fat, which is converted to ketone bodies by the liver, and which feedback on adipocytes. Full-length human HM74A shares 95% amino acid (aa) sequence identity with human HM74 and 81% aa sequence identity with mouse HM74A.
![HM74A/PUMA-G/GPR109A/NIACR1 Antibody (245106) [Allophycocyanin]](/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png "HM74A/PUMA-G/GPR109A/NIACR1 Antibody (245106) [Allophycocyanin]")
Secondary Antibodies |
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