Histone H3.3B Antibody (2D7-H1)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is poyadenylated, unlike most histone genes. The protein encoded is a member of the histone H3 family.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Xenopus.

We have publications tested in 1 application: KO.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using H00003021-M01	Applications	Species
Kelly B, Vanessa C, Jennifer Y et al. A knockout-first model of H3f3a gene targeting leads to developmental lethality. Genesis. 2023-01-19 [PMID: 36656301]
Jake R, Mike W, Brooke A et al. ARID1A-dependent maintenance of H3.3 is required for repressive CHD4-ZMYND8 chromatin interactions at super-enhancers. BMC Biol. 2022-09-25 [PMID: 36153585]
Xuemei W, Lu W, Jie D et al. Distinct role of histone chaperone Asf1a and Asf1b during fertilization and pre-implantation embryonic development in mice. Epigenetics Chromatin. 2021-12-14 [PMID: 34906203]
Hailiang M, Chisayo K, Ryoya H et al. H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos. Nat Genet. 2021-04-05 [PMID: 33821003]
Zhang K, Wang H, Rajput SK et al. Characterization of H3.3 and HIRA expression and function in bovine early embryos. Mol Reprod Dev 2017-12-12 [PMID: 29232016]
Pradhan SK, Su T, Yen L et al. EP400 Deposits H3.3 into Promoters and Enhancers during Gene Activation. Molecular Cell 2015-12-06 [PMID: 26669263]
Jang C, Shibata Y, Starmer J et al. Histone H3.3 maintains genome integrity during mammalian development. Genes Dev 2015-07-01 [PMID: 26159997] (KO, Mouse)	KO	Mouse
Hammoud SS, Low DH, Yi C et al. Chromatin and Transcription Transitions of Mammalian Adult Germline Stem Cells and Spermatogenesis. Cell Stem Cell. 2014-05-14 [PMID: 24835570]
Lin CJ, Conti M, Ramalho-Santos M. Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development. Development. 2013-09-01 [PMID: 23903189] (Mouse)		Mouse
Orsi GA, Algazeery A, Meyer RE et al. Drosophila Yemanuclein and HIRA Cooperate for De Novo Assembly of H3.3-Containing Nucleosomes in the Male Pronucleus. PLoS Genet. 2013-02-07 [PMID: 23408912]
Jullien J, Astrand C, Szenker E et al. HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes. Epigenetics Chromatin. 2012-01-01 [PMID: 23102146] (Xenopus)		Xenopus
Szenker E, Lacoste N, Almouzni G. A Developmental Requirement for HIRA-Dependent H3.3 Deposition Revealed at Gastrulation inXenopus. Cell Reports. 2012-01-01 [PMID: 22813747]
Sabirzhanov B, Keifer J. Cloning and Characterization of Glutamate Receptor Subunit 4 (GLUA4) and its Alternatively Spliced Isoforms in Turtle Brain. J Mol Neurosci. 2010-06-15 [PMID: 20549383]
Drane P, Ouararhni K, Depaux A et al. The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. Genes Dev. 2010-06-15 [PMID: 20504901]
Show All 14 Publications. Collapse Publications.

Array H00003021-M01

• Histone H3.3B Antibodies
• Histone H3.3B Lysate
• Histone H3.3B Proteins