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GRK1 Antibody

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Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55732] - Staining of human colon, eye, retina, liver and lymph node using Anti-GRK1 antibody NBP2-55732 (A) shows similar protein distribution across tissues to independent antibody NBP2-55226 (B).
Independent Antibodies: Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55732] - Staining of human colon, eye, retina, liver and lymph node using Anti-GRK1 antibody NBP2-55732 (A) shows similar protein ...read more
Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55732] - Staining of human retina shows strong cytoplasmic positivity in photoreceptor cells.
Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55732] - Staining of human colon.
Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55732] - Staining of human lymph node.
Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55732] - Staining of human liver.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
 

Independent Antibodies

        

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GRK1 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: FRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQL
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRK1
Purity
Affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:5000 - 1:10000
  • Immunohistochemistry-Paraffin 1:5000 - 1:10000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
GRK1 Recombinant Protein Antigen (NBP2-55732PEP)

Reactivity Notes

Mouse, Rat (88%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for GRK1 Antibody

  • G protein-coupled receptor kinase 1rhodopsin kinase
  • GPRK1
  • GRK1
  • RHOK
  • RHOKEC 2.7.11
  • RKEC 2.7.11.14

Background

The sensation of sight is the result of a cascade of events starting with the interaction of photoactivated rhodopsin with a protein called transducin. Rhodopsin kinase is a G-protein-coupled Ser/Thr kinase, also known as GRK1, which is a key element in the regulation of this cascade. Following phosphorylation by GRK1, arrestin is recruited to phospho-rhodopsin quenching its phototransductive activity by preventing further interaction with transducin. By breaking the cycle of phototransduction, GRK1 plays an important role in the restoration of the system for subsequent visual events.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol GRK1