| Reactivity | MuSpecies Glossary |
| Applications | Flow |
| Clone | 784808 |
| Clonality | Monoclonal |
| Host | Rat |
| Conjugate | Phycoerythrin |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse GPVI Gly24-Lys265 Accession # P0C191 |
| Specificity | Detects mouse GPVI in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human GPVI is observed. |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Host | Rat |
| Gene | GP6 |
| Purity | Protein A or G purified from hybridoma culture supernatant |
| Purity Statement | Protein A or G purified from hybridoma culture supernatant |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
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| Storage | Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light. |
| Buffer | Supplied in a saline solution containing BSA and Sodium Azide. |
| Preservative | Sodium Azide |
| Purity | Protein A or G purified from hybridoma culture supernatant |
GPVI (Platelet Glycoprotein VI), also known as Glycoprotein 5, is a member of the Ig superfamily. It is found on platelets and megakaryocytes, and serves as the main collagen receptor on platelets. Following exposure to subendothelial connective tissue, GPVI binds to a Gly-Pro-(hydroxy)Pro motif on collagen and generates a noncovalent membrane signaling complex with FcR gamma -chain. This interaction is stabilized by Integrin alpha 2 beta 1, followed by activation of PLC gamma 2 with clot initiation. Mature mouse GPVI is a 292 amino acid (aa) type I transmembrane protein. It possesses a 244 aa extracellular region (aa 22-265) that contains two C2-type Ig-like domains (aa 27-197)and two potential glycosylation sites, plus a 37 aa cytoplasmic tail (aa 287-313). There is one potential splice form that shows a deletion of aa 224-240. Over aa 24-265, mouse GPVI shares 70% and 86% aa identity with human and rat GPVI, respectively.
![GPVI Antibody (784808) [Phycoerythrin]](/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png "GPVI Antibody (784808) [Phycoerythrin]")
Secondary Antibodies |
Isotype Controls |
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