Name: Glutathione Peroxidase 1/GPX1 Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF3798
Price: 479 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, Mu, RtSpecies Glossary
Applications	WB, Simple Western, IHC, KO
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Immunogen	E. coli-derived recombinant human Glutathione Peroxidase 1 Gly48-Ala201 Accession # P07203
Specificity	Detects endogenous human, mouse, and rat GPX1. In Western blots, this antibody shows no cross-reactivity with recombinant human GPX2 or GPX3.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	GPX1
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Publications using AF3798	Applications	Species
Pamela Toh, Lucia A. Seale, Marla J. Berry, Daniel J. Torres Prolonged maternal exposure to glucocorticoids alters selenoprotein expression in the developing brain Frontiers in Molecular Neuroscience 2023-03-24 [PMID: 37033382]
Sara Evke, Qishan Lin, Juan Andres Melendez, Thomas John Begley Epitranscriptomic Reprogramming Is Required to Prevent Stress and Damage from Acetaminophen Genes (Basel) 2022-02-25 [PMID: 35327975]
Minati MA, Libert M, Dahou H et al. N-Acetylcysteine Reduces the Pro-Oxidant and Inflammatory Responses during Pancreatitis and Pancreas Tumorigenesis Antioxidants (Basel) 2021-07-11 [PMID: 34356340]
Minati MA, Libert M, Dahou H et al. N-Acetylcysteine Reduces the Pro-Oxidant and Inflammatory Responses during Pancreatitis and Pancreas Tumorigenesis Antioxidants (Basel) 7/11/2021 [PMID: 34356340]
Victor W. Kilonzo, Alexandru R. Sasuclark, Daniel J. Torres, Celine Coyle, Jennifer M. Pilat, Christopher S. Williams et al. Juvenile Selenium Deficiency Impairs Cognition, Sensorimotor Gating, and Energy Homeostasis in Mice Frontiers in Nutrition 2021-05-07 [PMID: 34026810]
Li Zhang, Bei Zhang, Linjing Wang, Mingwu Lou, Yunxia Shen Huanglian‑Houpo drug combination ameliorates H1N1‑induced mouse pneumonia via cytokines, antioxidant factors and TLR/MyD88/NF‑ kappa B signaling pathways Experimental and Therapeutic Medicine 2021-02-26 [PMID: 33747167]
Vuong Cat Khanh, Toshiharu Yamashita, Kinuko Ohneda, Chiho Tokunaga, Hideyuki Kato, Motoo Osaka et al. Rejuvenation of mesenchymal stem cells by extracellular vesicles inhibits the elevation of reactive oxygen species Scientific Reports 2020-10-14 [PMID: 33057147]
Y Chu, RS Lan, R Huang, H Feng, R Kumar, S Dayal, KS Chan, DF Dai Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice Aging Cell, 2020-05-13;0(0):. 2020-05-13 [PMID: 32400101] (Western Blot, Mouse)	Western Blot	Mouse
Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins et al. The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene Epigenetics 2020-10-02 [PMID: 32303148]
MY Lee, A Leonardi, TJ Begley, JA Melendez Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming? Redox Biol, 2019-11-11;28(0):101375. 2019-11-11 [PMID: 31765888] (Western Blot, Mouse)	Western Blot	Mouse
G Li, YL Chan, S Sukjamnong, AG Anwer, H Vindin, M Padula, R Zakarya, J George, BG Oliver, S Saad, H Chen A Mitochondrial Specific Antioxidant Reverses Metabolic Dysfunction and Fatty Liver Induced by Maternal Cigarette Smoke in Mice Nutrients, 2019-07-21;11(7):. 2019-07-21 [PMID: 31330878] (Western Blot, Mouse)	Western Blot	Mouse
Patrick M. Cowley, Guanying Wang, Philip M. Swigart, Anaha Raghunathan, Nikitha Reddy, Pranavi Dulam et al. Reversal of right ventricular failure by chronic alpha 1A-subtype adrenergic agonist therapy American Journal of Physiology-Heart and Circulatory Physiology 2019-01-01 [PMID: 30412439]
Wanghui Jing, Ane C. F. Nunes, Ted Farzaneh, Mahyar Khazaeli, Wei Ling Lau, Nosratola D. Vaziri Phosphate Binder, Ferric Citrate, Attenuates Anemia, Renal Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in 5/6 Nephrectomized CKD Rats Journal of Pharmacology and Experimental Therapeutics 2018-10-01 [PMID: 30093458]
P Youssef, B Chami, J Lim, T Middleton, GT Sutherland, PK Witting Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer's disease Sci Rep, 2018-08-01;8(1):11553. 2018-08-01 [PMID: 30068908] (Human)		Human
WL Lau, M Khazaeli, J Savoj, K Manekia, M Bangash, RG Thakurta, A Dang, ND Vaziri, B Singh Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy in 5/6 nephrectomized rats Pharmacol Res Perspect, 2018-02-19;6(2):e00385. 2018-02-19 [PMID: 29468071] (Western Blot, Rat)	Western Blot	Rat
V Coleman, P Sa-Nguanmo, J Koenig, TJ Schulz, T Grune, S Klaus, AP Kipp, M Ost Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling Sci Rep, 2018-02-05;8(1):2446. 2018-02-05 [PMID: 29402993] (Western Blot, Mouse)	Western Blot	Mouse
AN Ogawa-Wong, AC Hashimoto, H Ha, MW Pitts, LA Seale, MJ Berry Sexual Dimorphism in the Selenocysteine Lyase Knockout Mouse Nutrients, 2018-01-31;10(2):. 2018-01-31 [PMID: 29385050] (Western Blot, Mouse)	Western Blot	Mouse
W Jing, ND Vaziri, A Nunes, Y Suematsu, T Farzaneh, M Khazaeli, H Moradi LCZ696 (Sacubitril/valsartan) ameliorates oxidative stress, inflammation, fibrosis and improves renal function beyond angiotensin receptor blockade in CKD Am J Transl Res, 2017-12-15;9(12):5473-5484. 2017-12-15 [PMID: 29312499] (Western Blot, Rat)	Western Blot	Rat
Woo-Gyun Choi, Jaeseok Han, Ji-Hyeon Kim, Mi-Jeong Kim, Jae-Woo Park, Benbo Song et al. eIF2 alpha phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet Nutrition & Metabolism 2017-12-01 [PMID: 28781602]
Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis Nat Chem Biol, 2016-05-09;0(0):. 2016-05-09 [PMID: 27159577] (Western Blot, Human)	Western Blot	Human
Pitts MW, Kremer PM, Hashimoto AC et al. Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease. J. Neurosci. 11/18/2015 [PMID: 26586820] Details: Alpha Tubulin antibody used for WB as a loading control at a dilution of 1:5000 on mouse brainstem and whole-brain samples (Figure 6A).
Jing Wang, Arul Shanmugam, Shanu Markand, Eric Zorrilla, Vadivel Ganapathy, Sylvia B. Smith Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger Free Radical Biology and Medicine 2015-09-01 [PMID: 25920363]
Maria Z. Alfaradhi, Denise S. Fernandez-Twinn, Malgorzata S. Martin-Gronert, Barbara Musial, Abigail Fowden, Susan E. Ozanne Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2014-07-01 [PMID: 24789994]
Xiaosha Pang, Jun Panee Roles of Glutathione in Antioxidant Defense, Inflammation, and Neuron Differentiation in the Thalamus of HIV-1 Transgenic Rats Journal of Neuroimmune Pharmacology 2014-06-01 [PMID: 24609977]
Kurokawa S, Bellinger F, Hill K, Burk R, Berry M Isoform-specific binding of selenoprotein P to the beta-propeller domain of apolipoprotein E receptor 2 mediates selenium supply. J Biol Chem, 2014-02-13;289(13):9195-207. 2014-02-13 [PMID: 24532792] (Western Blot, Human)	Western Blot	Human
Byrns , China N, Pitts , Matthew, Gilman , Christy, Hashimoto , Ann C, Berry , Marla J Mice lacking selenoprotein P and selenocysteine lyase exhibit severe neurological dysfunction, neurodegeneration, and audiogenic seizures. J Biol Chem, 2014-02-11;289(14):9662-74. 2014-02-11 [PMID: 24519931] (Western Blot, Mouse)	Western Blot	Mouse
Rusolo , Fabiola, Pucci , Biagio, Colonna , Giovanni, Capone , Francesc, Guerriero , Eliana, Milone , Maria Ri, Nazzaro , Melissa, Volpe , Maria Gr, Di Bernardo , Gianni, Castello , Giuseppe, Costantini , Susan Evaluation of selenite effects on selenoproteins and cytokinome in human hepatoma cell lines. Molecules, 2013-02-26;18(3):2549-62. 2013-02-26 [PMID: 23442931] (Western Blot, Human)	Western Blot	Human
Musee J, Marnett L Prostaglandin H Synthase-2-catalyzed Oxygenation of 2-Arachidonoylglycerol Is More Sensitive to Peroxide Tone than Oxygenation of Arachidonic Acid. J Biol Chem, 2012-09-01;287(44):37383-94. 2012-09-01 [PMID: 22942274] (Western Blot, Mouse)	Western Blot	Mouse
Seale L, Hashimoto A, Kurokawa S, Gilman C, Seyedali A, Bellinger F, Raman A, Berry M Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice. Mol Cell Biol, 2012-08-13;32(20):4141-54. 2012-08-13 [PMID: 22890841] (Western Blot, Mouse)	Western Blot	Mouse
Spanier G, Xu H, Xia N Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J. Physiol. Pharmacol., 2009-10-01;60(0):111-6. 2009-10-01 [PMID: 20083859] (Western Blot, Human)	Western Blot	Human
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Glutathione Peroxidase 1/GPX1 Antibody [Unconjugated]

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Catalog# & Formulation	Size	Price
Carrier Free AF3798-SP

Gene Symbol	GPX1
Uniprot	P07203()