Glucocorticoid Receptor alpha Antibody - BSA Free

Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the Glucocorticoid Receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain GR. The human GR exists in two forms, alpha and beta, which are thought to be the result of alternative splicing of a single gene. Sequence analysis indicates that alpha and beta forms of human GR are 777 and 742 amino acids long, respectively. They are identical up to residue 727, after which they diverge. After ligand binding, the 94 kDa GR alpha isoform translocates from the cytoplasm to the nucleus where it regulates gene expression. In contrast, the 90 kDa GR beta isoform does not appear to bind either glucocorticoid agonists or antagonists, and has been localized predominantly in the nucleus independent of hormone treatment in some human cell lines. Studies suggest that human GR alpha has a greater affinity for GR response elements (GREs) than GR beta only when in the ligand bound state.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Chemotaxis, WB.

Showing Publications 1 - 4 of 4.

Publications using NB300-633	Applications	Species
Rodrigues VDST, Miranda RA, Soares PN et al. Neonatal nicotine exposure changes insulin status in fat depots: sex-related differences Journal of developmental origins of health and disease 2021-04-05 [PMID: 33818369]
Yari H, Jin L et al. LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription. Nat Commun 2019-11-25 [PMID: 31767869] (Chemotaxis, Human)	Chemotaxis	Human
Miranda RA, Pietrobon CB, Bertasso IM et al. Early weaning leads to specific glucocorticoid signalling in fat depots of adult rats Endocrine 2019-09-07 [PMID: 31494802]
Liang H, Kowalczyk P, Junco JJ et al. Differential Effects on Lung Cancer Cell Proliferation by Agonists of Glucocorticoid and PPARalpha Receptors. Mol Carcinog 2013-04-26 [PMID: 23625588] (WB, Human)	WB	Human

Array NB300-633

• Glucocorticoid Receptor alpha Antibody
• Glucocorticoid Receptor alpha ELISA Kits