Recombinant Human Gelsolin/GSN GST (N-Term) Protein

This product is produced by and distributed for Abnova, a company based in Taiwan.

Gelsolin is a calcium regulated actin binding protein. Gelsolin is a regulator of actin filament assembly and disassembly and consists of six homologous subdomains (S1-S6). When C-terminal tail (S6) is bound to calcium ion, it straightens and exposes actin binding sites located on S2s helices, leading to Gelsolin actin-serving activity (1). Gelsolin is inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2), where PIP2 will bind to S1, S2, and S3 sites. Gelsolin is involved in podosome formation and has been linked to inhibition of apoptosis by preventing release of cytochrome C (2).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

We have publications tested in 1 application: In vitro.

Showing Publication 1 - 1 of 1.

Publication using H00002934-Q01	Applications	Species
Conway JRW, Dinç DD, Follain G et al. IGFBP2 secretion by mammary adipocytes limits breast cancer invasion Science advances 2023-07-14 [PMID: 37436978] (In vitro) Details: Used in Inverted Invasion assay	In vitro

Array H00002934-Q01

• Gelsolin/GSN Antibodies
• Gelsolin/GSN ELISA Kits
• Gelsolin/GSN Lysate
• Gelsolin/GSN Proteins