GCH1 Antibody

GCH1 encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: Western Blot.

Showing Publication 1 - 1 of 1.

Publication using NBP1-79771	Applications	Species
Li H, Nguyen H, Meda Venkata SP et al. Novel Role of GPR35 (G-Protein-Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure Hypertension 2021-09-01 [PMID: 34275335] (Western Blot)	Western Blot

Array NBP1-79771

• GCH1 Antibodies
• GCH1 Lysates
• GCH1 Proteins