FSHR Antibody (6E8.2F5) - Azide and BSA Free Summary
Immunogen |
A synthetic peptide made to the human FSH R protein sequence (between residues 1-200). [Swiss-Prot P23945] |
Localization |
Cell membrane, Cytoplasm |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
FSHR |
Purity |
Protein G purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry 2-5 ug/ml
- Immunohistochemistry-Paraffin 2-5 ug/ml
- Western Blot 2-3 ug/ml
|
Application Notes |
The canonical isoform of FSHR is 78.3 kDa, however, it undergoes processing via glycosylation and the glycosylated protein runs at higher than predicted molecular weight. Under non-reducing conditions, FSHR may form dimers via disulfide bond formation. |
Reactivity Notes
Immunogen's sequence similarity with other species: Chicken and Duck (70%), Xenopus (71%).
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
PBS |
Preservative |
No Preservative |
Concentration |
1 mg/ml |
Purity |
Protein G purified |
Alternate Names for FSHR Antibody (6E8.2F5) - Azide and BSA Free
Background
Follicle-stimulating hormone (FSH), also called follitropin, belongs to the family of glycoprotein hormones that also includes luteininizing hormone and thyroid-stimulating hormone. These hormones are secreted by the pituitary and exist as heterodimers, consisting of a common alpha subunit and a homologous but distinct beta subunit. While the alpha subunit of FSH is involved in the binding of FSH to the receptor, follicle-stimulating hormone receptor (FSHR), the beta subunit stabilizes this interaction. This heterodimer regulates a variety of processes, including secretion, post-translational modification and signal transduction. Both FSH and FSHR are localized to Sertoli cells.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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