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FRS2 Antibody (462902)

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A172 human glioblastoma cell line was stained with Mouse Anti-Human FRS2 Monoclonal Antibody (Catalog # MAB40691, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG F(ab')2 Secondary Antibody (Catalog # F0101B). To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin.
A172 human glioblastoma cell line was stained with Mouse Anti-Human FRS2 Monoclonal Antibody (Catalog # MAB40691, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications CyTOF-ready, Flow
Clone
462902
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
IC40691U-100UG
Alexa Fluor 405
IC40691V-100UG
Alexa Fluor 488
IC40691G-100UG
Alexa Fluor 532
FAB40691X
Alexa Fluor 594
IC40691T-100UG
Alexa Fluor 647
IC40691R-100UG
Alexa Fluor 700
IC40691N-100UG
Alexa Fluor 750
IC40691S-100UG
Biotin
FAB40691B
CoraFluor 1
FAB40691CL1
DyLight 350
FAB40691D
DyLight 405
FAB40691E
DyLight 488
FAB40691K
DyLight 550
FAB40691L
DyLight 594
FAB40691M
DyLight 650
FAB40691W
DyLight 680
FAB40691Y
DyLight 755
FAB40691Z
FITC
FAB40691F
HRP
FAB40691H
Janelia Fluor 525
FAB40691JF525
Janelia Fluor 549
FAB40691I
Janelia Fluor 646
FAB40691J
Janelia Fluor 669
FAB40691JF669
PE
FAB40691P
PerCP
FAB40691C
mFluor Violet 450 SE
FAB40691MFV450
mFluor Violet 500 SE
FAB40691MFV500
mFluor Violet 610 SE
FAB40691MFV610
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB40691-SP
Carrier Free
IC40691N-100UG
Carrier Free
IC40691G-100UG
Carrier Free
IC40691V-100UG
Carrier Free
IC40691U-100UG
Carrier Free
IC40691T-100UG
Carrier Free
IC40691S-100UG
Carrier Free
IC40691R-100UG
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FRS2 Antibody (462902) Summary

Immunogen
E. coli-derived recombinant human FRS2
Asn121-Asn449
Accession # Q8WU20
Specificity
Detects human FRS2 in direct ELISAs.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
FRS2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Intracellular Staining by Flow Cytometry 2.5 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FRS2 Antibody (462902)

  • FGFR signalling adaptor
  • FGFR-signaling adaptor SNT
  • fibroblast growth factor receptor substrate 2
  • FRS2
  • FRS2A
  • FRS2alpha
  • SNT
  • SNT1
  • SNT-1FGFR substrate 2
  • Suc1-associated neurotrophic factor target 1

Background

FRS2 (FGFR substrate 2; also SNT and FSR2-alpha ) is a 70‑90 kDa member of the FSR family of lipid-anchored docking proteins. It is an intermediary between FGF and TRK receptors, and their Ras/MAPK signaling cascades. Human FRS2 is 512 amino acids (aa) in length. It contains a membrane-anchoring myristoylation signal (aa 1‑6), a PTB domain that interacts with FGF and NGF receptors (aa 13‑115), and a C-terminal Tyr-rich region that serves as a docking site for Grb2 and Shp2 (aa 196‑471). One splice form shows a deletion of the C-terminal four amino acids. Over aa 121‑449, human FRS2 is 99% and 94% aa identical to dog and mouse FRS2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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(462902)
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FRS2 Antibody (462902)
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Bioinformatics

Gene Symbol FRS2
Uniprot