Fetuin A/AHSG Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human Fetuin A, also known as alpha ₂-Heremans-Schmid glycoprotein, is encoded by the AHSG gene. It is a major plasma protein and a member of the cystatin superfamily of protease inhibitors (1, 2). It is expressed by hepatocytes, the principal cell source, and by monocyte/macrophages (3). The major form of plasma Fetuin A corresponds to a disulfide bond-linked two chains derived from the single chain (4). Human Fetuin A has a number of functions. It is a negative acute-phase protein with normal circulating levels in adults (300-600 μg/mL), which fall significantly (30-50%) during injury and infection (5). It enhances entry of cationic inhibitors into macrophages (6). It inhibits both insulin receptor autophosphorylation and undesirable calcification (6, 7). The purified rhFetuin A corresponds to the single chain, which can be converted to the two-chain form by rhFurin (R&D Systems, Catalog # 1503-SE) in vitro. However, the conversion does not enhance its inhibitory activity against rhCathpesin V, a cysteine protease.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ELISA Detection, IHC-P, Western Blot.

Showing Publications 1 - 5 of 5.

Publications using AF1184	Applications	Species
H Uedono, K Mori, A Ochi, S Nakatani, Y Miki, A Tsuda, T Morioka, Y Nagata, Y Imanishi, T Shoji, M Inaba, M Emoto Effects of fetuin-A-containing calciprotein particles on posttranslational modifications of fetuin-A in HepG2 cells Scientific Reports, 2021-04-05;11(1):7486. 2021-04-05 [PMID: 33820929] (Western Blot, Human)	Western Blot	Human
Cao J, O'Day DR, Pliner HA et al. A human cell atlas of fetal gene expression Science 11/13/2020 [PMID: 33184181]
C Sujana, C Huth, A Zierer, S Meesters, J Sudduth-Kl, W Koenig, C Herder, A Peters, B Thorand Association of fetuin-A with incident type 2 diabetes: Results from the MONICA/KORA Augsburg study and a systematic meta-analysis Eur. J. Endocrinol., 2018-02-08;0(0):. 2018-02-08 [PMID: 29439057] (ELISA Detection, Human)	ELISA Detection	Human
Li , Qiaoli, Brodsky , Jill L, Conlin , Laura K, Pawel , Bruce, Glatz , Andrew C, Gafni , Rachel I, Schurgers , Leon, Uitto , Jouni, Hakonarson , Hakon, Deardorff , Matthew, Levine , Michael Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: genotypic overlap with pseudoxanthoma elasticum. J Invest Dermatol, 2013-09-05;134(3):658-65. 2013-09-05 [PMID: 24008425] (IHC-P, Human)	IHC-P	Human
Li Q, Grange DK, Armstrong NL, Whelan AJ, Hurley MY, Rishavy MA, Hallgren KW, Berkner KL, Schurgers LJ, Jiang Q, Uitto J Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes. J. Invest. Dermatol., 2008-09-18;129(3):553-63. 2008-09-18 [PMID: 18800149] (IHC-P, Human)	IHC-P	Human

Array AF1184

• Fetuin A/AHSG Antibodies
• Fetuin A/AHSG Antibody Pairs
• Fetuin A/AHSG ELISA Kits
• Fetuin A/AHSG Lysate
• Fetuin A/AHSG Proteins
• Fetuin A/AHSG ELISAs
• Fetuin A/AHSG Proteins and Enzymes