Fas Ligand/TNFSF6 Antibody (A11)

Fas / APO-1 (CD95) is an important member of the tumour necrosis factor (TNF) superfamily involved in membrane-mediated apoptosis. Ligation of Fas by Fas Ligand (Fas-L) or an anti-Fas cross-linking antibody, triggers activation of the caspase cascade. Functional impairment of the Fas / Fas-L system is associated with the development and progression of malignancies. Fas gene mutations have been suggested to have a role in testicular germ cell tumours. Tumour cells frequently exhibit de novo expression of Fas Ligand (Fas-L), which plays a significant role in local tissue destruction, metastatic spread, and immune escape of the tumor cells. The apoptosis of lymphocytes, which occurs in autoimmune diseases, is usually induced by the Fas/Fas-L system. Fas is believed to be involved in various autoimmune diseases including, ulcerative colitis, Graves disease, and rheumatoid arthritis. Fas expression on gastric epithelial cells in patients infected with H.Pylori is responsible for the accelerated apoptosis of the cells. Serum Fas-L concentration has also been shown to be associated with atherosclerosis and inflammatory disease, in patients with hypertension.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: FLOW, ICC/IF, IHC-Fr.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NBP1-97519	Applications	Species
Harding J, Vintersten-Nagy K, Yang H et al. Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts Nature biomedical engineering 2023-11-23 [PMID: 37996616] (FLOW, ICC/IF, Mouse)	FLOW, ICC/IF	Mouse
I Viard-Leveugle et al. Intracellular localization of keratinocyte Fas ligand explains lack of cytolytic activity under physiological conditions. J. Biol. Chem. 278, 16183. 2003-01-01 [PMID: 12473659]
M Sata et al. Fas ligand overexpression on allograft endothelium inhibits inflammatory cell infiltration and transplant-associated intimal hyperplasia. J. Immunol. 166, 6964. 2001-01-01 [PMID: 11359858]
JH Li et al. The regulation of CD95 ligand expression and function in CTL. J. Immunol. 161, 3943. 1998-01-01 [PMID: 9780162]
Y Refaeli et al. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 8, 615. 1998-01-01 [PMID: 9620682]
P Saas et al. Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?. J. Clin. Invest. 99, 1173. 1997-01-01 [PMID: 9077524]
M Hahne et al. Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape. Science 274, 1363. 1996-01-01 [PMID: 8910274]
T Renno et al. Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand. J. Exp. Med. 183, 431. 1996-01-01 [PMID: 8627156]
LE French et al. Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover. J. Cell. Biol. 133, 335. 1996-01-01 [PMID: 8609166]
M Sata et al. Vascular endothelial cells and smooth muscle cells differ in expression of Fas and Fas ligand and in sensitivity to Fas ligand-induced cell death: implications for vascular disease and therapy. Arterioscler. Thromb. Vasc. Biol. 20, 309. 2000-01-01 [PMID: 7510950]
Hahne M, Peitsch MC, Irmler M et al. Characterization of the non-functional Fas ligand of gld mice. Int Immunol. 1995-09-01 [PMID: 7495745]
Harding J, Vintersten-Nagy K, Shutova M, Yang H Induction of long-term allogeneic cell acceptance and formation of immune privileged tissue in immunocompetent Hosts bioRxiv 2019-07-30 (ICC/IF, IHC-Fr, Mouse)	ICC/IF, IHC-Fr	Mouse
Show All 12 Publications. Collapse Publications.

Array NBP1-97519

• Fas Ligand/TNFSF6 Antibodies
• Fas Ligand/TNFSF6 ELISA Kits
• Fas Ligand/TNFSF6 Lysate
• Fas Ligand/TNFSF6 Protein
• Fas Ligand/TNFSF6 Proteins and Enzymes
• Fas Ligand/TNFSF6 ELISAs