Fas Ligand/TNFSF6 Antibody (100419) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a 40 kDa type II transmembrane member of the TNF superfamily of proteins. Its ability to induce apoptosis in target cells plays an important role in the development, homeostasis, and function of the immune system (1). Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain (2). Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Both mouse and human Fas Ligand are active on mouse and human cells (2, 3). Fas Ligand is expressed on the cell surface as a nondisulfide-linked homotrimer on activated CD4+ Th1 cells, CD8+ cytotoxic T cells, and NK cells (1). Fas Ligand binding to Fas/CD95 on an adjacent cell triggers apoptosis in the Fas‑expressing cell (2, 4). Fas Ligand also binds DcR3 which is a soluble decoy receptor that interferes with Fas Ligand-induced apoptosis (5). Fas Ligand can be released from the cell surface by metalloproteinases as a 26 kDa soluble molecule which remains trimeric (6, 7). Shed Fas Ligand retains the ability to bind Fas, although its ability to trigger apoptosis is dramatically reduced (6, 7). In the absence of TGF‑ beta , however, Fas Ligand/Fas interactions instead promote neutrophil-mediated inflammatory responses (3, 8). Fas Ligand itself transmits reverse signals that costimulate the proliferation of freshly antigen-stimulated T cells (9). Fas Ligand-induced apoptosis plays a central role in the development of immune tolerance and the maintance of immune privileged sites (10). This function is exploited by tumor cells which evade immune surveillance by upregulating Fas Ligand to kill tumor infiltrating lymphocytes (8, 11). In gld mice, a Fas Ligand point mutation is the cause of severe lymphoproliferation and systemic autoimmunity (12, 13).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Functional Assay, Neutralization.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using MAB126	Applications	Species
S Shankar, J Stolp, SC Juvet, J Beckett, PS Macklin, F Issa, J Hester, KJ Wood Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis Nature Communications, 2022-06-03;13(1):3121. 2022-06-03 [PMID: 35660734] (Neutralization, Human)	Neutralization	Human
Xueyang Guo, Alexandra Kazanova, Stephanie Thurmond, H. Uri Saragovi, Christopher E. Rudd Effective chimeric antigen receptor T cells against SARS-CoV-2 iScience 11/19/2021 [PMID: 34693218]
O Kajikawa, R Herrero, YH Chow, CF Hung, G Matute-Bel The bioactivity of soluble Fas ligand is modulated by key amino acids of its stalk region PLoS ONE, 2021-06-17;16(6):e0253260. 2021-06-17 [PMID: 34138914] (Functional Assay, Human)	Functional Assay	Human
B Liu, Y Zhang, Y Fan, S Wang, Z Li, M Deng, C Li, J Wang, R Ma, X Wang, Y Wang, L Xu, K Hou, X Che, Y Liu, X Qu Leucine-rich repeat neuronal protein-1 suppresses apoptosis of gastric cancer cells through regulation of Fas/FasL Cancer Sci., 2019-06-10;110(7):2145-2155. 2019-06-10 [PMID: 31087525] (Neutralization, Human)	Neutralization	Human
M Idelson, R Alper, A Obolensky, N Yachimovic, J Rachmilewi, A Ejzenberg, E Beider, E Banin, B Reubinoff Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Stem Cell Reports, 2018-08-16;0(0):. 2018-08-16 [PMID: 30122442] (Neutralization, Human)	Neutralization	Human
M Kim, S Pyo, CH Kang, CO Lee, HK Lee, SU Choi, CH Park Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer PLoS ONE, 2018-06-06;13(6):e0198347. 2018-06-06 [PMID: 29874279] (Neutralization, Human)	Neutralization	Human
S Nakachi, S Sumitomo, Y Tsuchida, H Tsuchiya, M Kono, R Kato, K Sakurai, N Hanata, Y Nagafuchi, S Tateishi, H Kanda, T Okamura, K Yamamoto, K Fujio Interleukin-10-producing LAG3(+) regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis Arthritis Res. Ther., 2017-05-16;19(1):97. 2017-05-16 [PMID: 28511719] (Neutralization, Human)	Neutralization	Human
N Köstlin, M Vogelmann, B Spring, J Schwarz, J Feucht, C Härtel, TW Orlikowsky, CF Poets, C Gille Granulocytic myeloid derived suppressor cells from human cord blood modulate T-helper-cell response towards an anti-inflammatory phenotype Immunology, 2017-06-08;0(0):. 2017-06-08 [PMID: 28464218] (Neutralization, Human)	Neutralization	Human
MC Tanzer, N Khan, JA Rickard, N Etemadi, N Lalaoui, SK Spall, JM Hildebrand, D Segal, M Miasari, D Chau, WL Wong, M McKinlay, SK Chunduru, CA Benetatos, SM Condon, JE Vince, MJ Herold, J Silke Combination of IAP antagonist and IFN? activates novel caspase-10- and RIPK1-dependent cell death pathways Cell Death Differ, 2017-01-20;0(0):. 2017-01-20 [PMID: 28106882] (Neutralization, Human)	Neutralization	Human
ME Guicciardi, A Krishnan, SF Bronk, P Hirsova, TS Griffith, GJ Gores Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice Cell Death Dis, 2017-01-05;8(1):e2535. 2017-01-05 [PMID: 28055006] (Neutralization, Human)	Neutralization	Human
Zheng J, Wu W, Liu Y, Xiang Z, Liu M, Chan K, Lau S, Lam K, To K, Chan J, Li L, Chen H, Lau Y, Yuen K, Tu W The Therapeutic Effect of Pamidronate on Lethal Avian Influenza A H7N9 Virus Infected Humanized Mice. PLoS ONE, 2015-08-18;10(8):e0135999. 2015-08-18 [PMID: 26285203] (Neutralization, Human)	Neutralization	Human
Yang , Kai-Lin, Wang , Yu-Shan, Chang , Chao-Chu, Huang , Su-Chen, Huang , Yi-Chun, Chi , Mau-Shin, Chi , Kwan-Hwa Reciprocal complementation of the tumoricidal effects of radiation and natural killer cells. PLoS ONE, 2013-04-25;8(4):e61797. 2013-04-25 [PMID: 23634213] (Neutralization, Human)	Neutralization	Human
Inoue T, Tashiro Y, Takeuchi M Potent anti-tumor killing activity of the multifunctional Treg cell line HOZOT against human tumors with diverse origins. Int. J. Oncol., 2011-03-03;38(5):1299-306. 2011-03-03 [PMID: 21373756] (Neutralization, Human)	Neutralization	Human
Navenot JM, Fujii N, Peiper SC KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis. Mol. Pharmacol., 2009-02-06;75(5):1074-83. 2009-02-06 [PMID: 19201817] (Neutralization, Human)	Neutralization	Human
Krysov SV, Krysov</LastName><ForeNam SV</Initia, Rowley TF, Al-Shamkhani A Inhibition of p38 mitogen-activated protein kinase unmasks a CD30-triggered apoptotic pathway in anaplastic large cell lymphoma cells. Mol. Cancer Ther., 2007-02-01;6(2):703-11. 2007-02-01 [PMID: 17308066] (Neutralization, Human)	Neutralization	Human
Georgopoulos NT, Steele LP, Thomson MJ, Selby PJ, Southgate J, Trejdosiewicz LK A novel mechanism of CD40-induced apoptosis of carcinoma cells involving TRAF3 and JNK/AP-1 activation. Cell Death Differ., 2006-01-20;13(10):1789-801. 2006-01-20 [PMID: 16429118] (Neutralization, Human)	Neutralization	Human
Show All 16 Publications. Collapse Publications.

Array MAB126

• Fas Ligand/TNFSF6 Antibodies
• Fas Ligand/TNFSF6 ELISA Kits
• Fas Ligand/TNFSF6 Lysate
• Fas Ligand/TNFSF6 Protein
• Fas Ligand/TNFSF6 Proteins and Enzymes
• Fas Ligand/TNFSF6 ELISAs