ER alpha/NR3A1 Antibody

Estrogen Receptor alpha is a 65 kDa protein and a member of the steroid family of nuclear receptors. Estrogen Receptor alpha is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change that allows dimerization and binding to estrogen response element sequences. When bound to DNA, Estrogen Receptor alpha can positively or negatively regulate gene transcription. Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins. Estrogen Receptors play an important role in regulating mammary gland growth and differentiation. Breast tumors that are ER positive may also show a more favorable response to anti-estrogen therapies

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publication 1 - 1 of 1.

Publication using NB100-81909	Applications	Species
Tantengco O, Richardson L, Mennon R Effects of a gestational level of estradiol on cellular transition, migration, and inflammation in cervical epithelial and stromal cells Am J Reprod Immunol 2020-11-05 [PMID: 33152143]

Images	Ratings	Applications	Species	Date	Details
	1 reviewed by: Verified Customer	IHC-P	Horse	11/27/2023	View Summary Application Immunohistochemistry-Paraffin Sample Tested Oviduct Species Horse Lot 220299 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody.*** NB100-81909 was left on tissue sections for 30m at room temperature and was diluted up to 2ug per mL. Two different buffers for heat-induced epitope retrieval were also tested. Longer incubation times and higher concentrations were not tested due to finding nonspecific labeling of smooth muscle and other tissue elements.
	1 reviewed by: Verified Customer	IHC-P	Cat	11/27/2023	View Summary Application Immunohistochemistry-Paraffin Sample Tested Uterus Species Cat Lot 220299 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody.*** NB100-81909 was left on tissue sections for 30m at room temperature and was diluted up to 2ug per mL. Longer incubation times and higher concentrations were not tested due to finding nonspecific labeling of tissue elements like smooth muscle.
	1 reviewed by: Verified Customer	IHC-P	Dog	11/27/2023	View Summary Application Immunohistochemistry-Paraffin Sample Tested Oviduct Species Dog Lot 220299 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody.*** NB100-81909 was left on tissue sections for 30m at room temperature and was diluted up to 2ug per mL. Longer incubation times and higher concentrations were not tested due to finding nonspecific labeling of smooth muscle.
Enlarge	5 reviewed by: Verified Customer	ICC	Human	01/20/2021	View Summary Application Immunocytochemistry Sample Tested Cervical stromal cells Species Human Lot 8205 Comments Comments 1:200 dilution in 3% BSA ***Novus Innovators Program - new species or application used on a primary antibody.
Enlarge	4 reviewed by: Jessica Hill	Simple Western	Mouse	06/15/2018	View Summary Application Simple Western Sample Tested Adipose tissue Species Mouse Lot 5117 Comments Comments subcutaneous adipose tissue (the inguinal fat pad), in 5XSDS loading buffer was plated at 1mg/mL. The pAb was used at a 1:10 concentration (along with GAPDH at 1:10). The antibody worked fine on our samples.

Array NB100-81909

• ER alpha/NR3A1 Antibodies
• ER alpha/NR3A1 Lysates
• ER alpha/NR3A1 Proteins
• ER alpha/NR3A1 ELISA