DMP-1 Antibody

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NBP1-89484	Applications	Species
Shunsuke Kawai, Junko Sunaga, Sanae Nagata, Megumi Nishio, Masayuki Fukuda, Takeshi Kamakura, Liping Sun, Yonghui Jin, Satoko Sakamoto, Akira Watanabe, Shuichi Matsuda, Taiji Adachi, Junya Toguchida 3D osteogenic differentiation of human iPSCs reveals the role of TGF beta signal in the transition from progenitors to osteoblasts and osteoblasts to osteocytes Scientific Reports 2023-01-19 [PMID: 36658197]

Array NBP1-89484

• DMP-1 Antibodies
• DMP-1 Protein
• DMP-1 Proteins and Enzymes
• DMP-1 ELISA