Defensin alpha 5 Antibody (8C8)

Defensins are a kind of endogenous antimicrobial peptide enriched with cysteine/arginine and are widely distributed in internal organs wherein they are recognized as defenders against invasion by pathogenic organisms. Human alpha-defensins (human alpha-defensins 5, -6, and human neutrophil peptides-1, -2, -3, -4) are a class of small antimicrobial peptides with well characterized antibacterial activity against both Gram +ve as well as Gram-ve bacteria, and certain viruses such as such as HSV, HPV, adenovirus and polyoma virus. Human alpha-defensin 5 (HD5) is a 32 amino acids long protein that shares a common structural feature of alpha-defensin family characterized by three-stranded anti-parallel beta-sheets stabilized by three intra-molecular disulfide bridges. HD5 is primarily expressed in small intestinal Paneth cells or epithelial cells of urino-genital tract, and it is found in cytoplasmic vesicle/secretory vesicle or in secreted form. Peptides HD5(20-94), HD5(23-94) and HD5(29-94) are found within tissues among which HD5(20-94) is the predominant intracellular form. In extracellular milieu, peptides HD5(56-94) and HD5(63-94) are found and among these two peptides, HD5 (63-94) is the most abundant form.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 9 applications: Cytometric Bead Assay Standard, ELISA, ICC/IF, IF/IHC, IHC-Fr, IHC-P, Immunocytochemistry/ Immunofluorescence, WB, Western Blot.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using NB110-60002	Applications	Species
Hoffmann S Characterization and establishment of advanced intestinal cell culture models and the evaluation of potential new biomarkers for the prediction of drug-induced intestinal toxicity Thesis 2023-01-01 (Western Blot, Human)	Western Blot	Human
Balasubramanian I, Bandyopadhyay S, Flores J et al. Infection and inflammation stimulate expansion of a CD74+ Paneth cell subset to regulate disease progression The EMBO journal 2023-09-18 [PMID: 37718683] (ICC/IF, Human)	ICC/IF	Human
Che YH, Choi IY, Song CE et al. Peripheral Neuron-Organoid Interaction Induces Colonic Epithelial Differentiation via Non-Synaptic Substance P Secretion International Journal of Stem Cells 2023-08-30 [PMID: 37385635] (ELISA, Western Blot, Immunocytochemistry/ Immunofluorescence)	ELISA, Western Blot, Immunocytochemistry/ Immunofluorescence
McCauley HA, Riedman AM, Enriquez JR et al. Enteroendocrine Cells Protect the Stem Cell Niche by Regulating Crypt Metabolism in Response to Nutrients Cellular and Molecular Gastroenterology and Hepatology 2023-01-04 [PMID: 36608902] (Immunocytochemistry/ Immunofluorescence)	Immunocytochemistry/ Immunofluorescence
Lim A, Nadkarni R, Courteau B, Draper J Comparison of human and mouse fetal intestinal tissues reveals differential maturation timelines bioRxiv 2020-06-19 (IHC-P, IF/IHC, Human)	IHC-P, IF/IHC	Human
Liu TC, Kern JT, Jain U et al. Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation Cell host & microbe 2021-05-12 [PMID: 34010595]
Sanchez J, Rankin S, Paul E et al. Human organoid modeling of congenital malformations caused by RFX6 mutations reveal an essential role for this transcription factor in establishing and maintaining duodenal identity upstream of PDX1 bioRxiv 2023-11-11
Jabari S, Schrodl F, Kaser-Eichberger A et al. Alarin in different human intestinal epithelial cell types. Histochem. Cell Biol. 2019-01-05 [PMID: 30612153] (IHC-Fr, Human)	IHC-Fr	Human
Cerrillo E, Moret I, Iborra M et al. Alpha-defensins (a-Defs) in Crohn's disease: Decrease of ileal a-Def 5 via permanent methylation and increase in plasma a-Def 1-3 concentrations offering biomarker utility Clin. Exp. Immunol. 2017-11-28 [PMID: 29193023] (Human)		Human
Múnera JO, Sundaram N, Rankin SA et al. Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling. Cell Stem Cell. 2017-06-20 [PMID: 28648364]
Liu TC, Naito T, Liu Z et al. LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients. JCI Insight. 2017-03-23 [PMID: 28352666] (IHC-P, Human)	IHC-P	Human
Liu TC, Gurram B, Baldridge MT et al. Paneth cell defects in Crohn's disease patients promote dysbiosis. JCI Insight 2016-06-02 [PMID: 27699268]
Kim HJ, Kang UB, Lee H et al. Profiling of differentially expressed proteins in stage IV Colorectal cancers with good and poor outcomes. J Proteomics. 2011-12-10 [PMID: 22178445]
Jung JH, Kim HJ, Yeom J, Yoo C, Shin J, Yoo J, Kang CS, Lee C. Lowered expression of galectin-2 is associated with lymph node metastasis in gastric cancer. J Gastroenterol;47(1):37-48. 2012-01-01 [PMID: 22015694] (WB, Human)	WB	Human
Bukurova IuA, Nikitina SL, Khankin SL et al. Identification of protein markers for serum diagnosis of cancer based on microRNA expression profiling. Mol Biol (Mosk) 2011-03-01 [PMID: 21634125] (WB, Human)	WB	Human
Wehkamp, J et al. Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues. FEBS Lett;580(22):5344-50. 2006-10-02 [PMID: 16989824] (ICC/IF, IF/IHC, Human)	ICC/IF, IF/IHC	Human
Wehkamp, J et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A;102(50):18129-34. 2005-12-13 [PMID: 16330776] (IF/IHC, WB, Human)	IF/IHC, WB	Human
Shen B, Porter EM, Reynoso E, Shen C, Ghosh D, Connor JT, Drazba J, Rho HK, Gramlich TL, Li R, Ormsby AH, Sy MS, Ganz T, Bevins CL. Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract. J Clin Pathol;58(7):687-94. 2005-07-01 [PMID: 15976333] (WB, ELISA, IF/IHC, Cytometric Bead Assay Standard, IHC-P, Human)	WB, ELISA, IF/IHC, Cytometric Bead Assay Standard, IHC-P	Human
Show All 18 Publications. Collapse Publications.

Array NB110-60002

• Defensin alpha 5 Antibodies
• Defensin alpha 5 ELISA Kits
• Defensin alpha 5 Lysate
• Defensin alpha 5 Protein