DARPP-32 [p Thr34] Antibody - Azide Free

DARPP-32, a dopamine (DA) and cAMP-regulated ~32k phosphoprotein, is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine, and Prozac.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 4 of 4.

Publications using NB300-224	Applications	Species
Yabuki Y, Ohizumi Y, Yokosuka A et al. Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice. Neuroscience 2013-12-04 [PMID: 24316474] (WB, Mouse)	WB	Mouse
Hamel S, Bouchard A, Ferrario C et al. Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers Breast Cancer Res Treat 2010-02-01 [PMID: 19301121] (IF/IHC, Human)	IF/IHC	Human
Shioda N, Han F, Moriguchi S et al. Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia. J Neurochem. 2007-09-01 [PMID: 17662023] (WB, Mouse) Details: DARP-32 (IMG-5373): WB (mouse brain tissue), Fig 2B.	WB	Mouse
Han, J et al. Spatial targeting of type II protein kinase A to filopodia mediates the regulation of growth cone guidance by cAMP. J Cell Biol 176: 101-111. 2007-01-01 [PMID: 17200417] (WB, Rat)	WB	Rat

Array NB300-224

• DARPP-32 Antibodies
• DARPP-32 ELISA Kits
• DARPP-32 Lysates
• DARPP-32 Proteins