DARPP-32 Products

Description

DARPP-32, a dopamine (DA) and cAMP-regulated ~32k phosphoprotein, is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac

Bioinformatics

Entrez	19049 Mouse 360616 Rat 84152 Human
Uniprot	AAH01519 Human NM_032192 Human NM_181505 Human NP_115568.2 Human Q6J4I0 Rat Q9UD71 Human
Product By Gene ID	84152
Alternate Names	protein phosphatase 1, regulatory (inhibitor) subunit 1B regulatory (inhibitor) subunit 1B (dopamine and cAMPregulated phosphoprotein, DARPP-32)

Research Areas for DARPP-32

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Neuronal Cell Markers
Neuroscience
Neurotransmission
Phospho-Specific
Protein Phosphatase
Signal Transduction