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Cytosolic Sulfotransferase 1B1/SULT1B1 Antibody (724429)

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Cytosolic Sulfotransferase 1B1/SULT1B1 was detected in immersion fixed paraffin-embedded sections of human liver using Mouse Anti-Human Cytosolic Sulfotransferase 1B1/SULT1B1 Monoclonal Antibody (Catalog # MAB5959) at ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
724429
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

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Cytosolic Sulfotransferase 1B1/SULT1B1 Antibody (724429) Summary

Immunogen
E. coli-derived recombinant human Cytosolic Sulfotransferase 1B1/SULT1B1
Leu2-Ile296
Accession # O43704
Specificity
Detects human Cytosolic Sulfotransferase 1B1/SULT1B1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) SULT1A1, rhSULT1C1, or rhSULT1E1 is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
SULT1B1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 8-25 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cytosolic Sulfotransferase 1B1/SULT1B1 Antibody (724429)

  • Cytosolic Sulfotransferase 1B1
  • EC 2.8.2
  • EC 2.8.2.-
  • EC 2.8.2.1
  • EC 2.8.2.4
  • MGC13356
  • ST1B1
  • ST1B2
  • ST1B2sulfotransferase family cytosolic 1B member 1
  • Sulfotransferase 1B1
  • Sulfotransferase 1B2
  • sulfotransferase family, cytosolic, 1B, member 1
  • SULT1B1
  • SULT1B2
  • Thyroid hormone sulfotransferase

Background

Cytosolic Sulfotransferases are a family of phase II drug-metabolizing enzymes that catalyze the sulfation of many endogenous and xenobiotic substrates (1‑3). They have important functions in the metabolism of many endogenous compounds including steroids, bile acids, thyroid hormones and monoamine neurotransmitters. They are distributed throughout the body and serve to inactivate and increase water-solubility of xenobiotics and therapeutic drugs. Cytosolic sulfotransferases are distinct from Golgi resident sulfotransferases by lacking N-terminal signal-anchorage domains and residing only in the cytoplasm. SULT1B1 is primarily expressed in the liver, peripheral blood leukocytes, colon, spleen and small intestine and can sulfate thyroid hormones and small phenols (4). Human SULT1B1 shares 72% amino acid sequence identity with mouse SULT1B1.

  1. Falany, C, N. (1997) FASEB J. 11:206.
  2. Gamage, N. U. et al. (2006) Toxicol. Sci. 90:5.
  3. Allali-Hassani, A. et al. (2007) PLoS Biol. 5:e97.
  4. Wang, J. et al. (1998) Mol. Pharmacol. 53:274.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SULT1B1
Uniprot