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CXCL10/IP-10/CRG-2 Antibody [Biotin]

 (19 Publications)
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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA(Det), Flow
Clonality
Polyclonal
Host
Goat
Conjugate
Biotin
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Unconjugated
AF-266-NA
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
AF-266-NA
Carrier Free
AF-266-NA
Carrier Free
AF-266-SP
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CXCL10/IP-10/CRG-2 Antibody [Biotin] Summary

Immunogen
E. coli-derived recombinant human CXCL10/IP-10
Specificity
Detects human CXCL10/IP-10/CRG-2 in ELISAs and Western blots. In sandwich ELISAs, less than 0.1% cross-reactivity with recombinant mouse CRG‑2, recombinant human (rh) Lymphotactin, rhGRO alpha , and rhMIG is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
CXCL10
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
  • Intracellular Staining by Flow Cytometry 2.5 ug/10^6 cells
Application Notes
ELISA Capture: Human CXCL10/IP-10/CRG-2 Antibody (Catalog # MAB266)
ELISA Detection: Human CXCL10/IP-10/CRG-2 Biotinylated Antibody (Catalog # BAF266)
Standard: Recombinant Human CXCL10/IP-10/CRG-2 (Catalog # 266-IP)
Readout System
Publications
Read Publications using
BAF266 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL10/IP-10/CRG-2 Antibody [Biotin]

  • C7
  • chemokine (C-X-C motif) ligand 10
  • CRG2
  • CRG-2
  • CXCL10
  • gIP-10
  • IFI10
  • INP10
  • IP-10
  • mob-1
  • SCYB10

Background

CXCL10 was originally identified as an IFN-gamma -inducible gene in monocytes, fibroblasts, and endothelial cells. It has since been shown that CXCL10 mRNA is also induced by LPS, IL-1 beta , TNF-alpha , IL-12, and viruses. Additional cell types that have been shown to express CXCL10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. CXCL10 is also expressed in psoriatic and lepromatous lesions of skin. The mouse homologue of human CXCL10, CRG-2, has been cloned and shown to share approximately 67% amino acid (aa) sequence identity with human CXCL10. Human CXCL10 cDNA encodes a 98 aa residue precursor protein with a 21 aa residue signal peptide that is cleaved to form the 77 aa residue secreted protein. The amino acid sequence of CXCL10 identified the protein as a member of the chemokine alpha subfamily that lacks the ELR domain. CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes. CXCL10 has been reported to be a potent inhibitor of angiogenesis and to display a potent thymus-dependent anti-tumor effect. A chemokine receptor specific for CXCL10 and MIG has been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes.

  1. Loetscher, M. et al. (1996) J. Exp. Med. 184:963.
  2. Wang, X. et al. (1996) J. Biol. Chem. 271:24286.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CXCL10/IP-10/CRG-2 Antibody (BAF266)(19)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: ELISA Detection, ELISA Development, ELISA Development (Detection), ICC, Luminex Development.


Filter By Application
ELISA Detection
(2)
ELISA Development
(8)
ELISA Development (Detection)
(2)
ICC
(1)
Luminex Development
(4)
All Applications
Filter By Species
Human
(17)
All Species
Showing Publications 1 - 10 of 19. Show All 19 Publications.
Publications using BAF266 Applications Species
R Ravindran, C McReynolds, J Yang, BD Hammock, A Ikram, A Ali, A Bashir, T Zohra, WLW Chang, DJ Hartigan-O, HH Rashidi, IH Khan Immune response dynamics in COVID-19 patients to SARS-CoV-2 and other human coronaviruses PLoS ONE, 2021-07-09;16(7):e0254367. 2021-07-09 [PMID: 34242356] (ELISA Detection, Human) ELISA Detection Human
C Kötting, L Hofmann, R Lotfi, D Engelhardt, S Laban, PJ Schuler, TK Hoffmann, C Brunner, MN Theodoraki Immune-Stimulatory Effects of Curcumin on the Tumor Microenvironment in Head and Neck Squamous Cell Carcinoma Cancers, 2021-03-16;13(6):. 2021-03-16 [PMID: 33809574] (ELISA Detection, Human) ELISA Detection Human
Nikki P. L. Toledo, Hongzhao Li, Robert W. Omange, Tamara G. Dacoba, Jose Crecente-Campo, Dane Schalk et al. Cervico-Vaginal Inflammatory Cytokine and Chemokine Responses to Two Different SIV Immunogens Frontiers in Immunology 2020-08-25 [PMID: 32983121]
Sara Abouelasrar Salama, Mieke Gouwy, Alexandra De Zutter, Noëmie Pörtner, Lotte Vanbrabant, Nele Berghmans et al. Induction of Chemokines by Hepatitis C Virus Proteins: Synergy of the Core Protein with Interleukin-1 beta and Interferon-gamma in Liver Bystander Cells Journal of Interferon & Cytokine Research 2020-04-01 [PMID: 32031878]
Association of MIF, but not type I interferon-induced chemokines, with increased disease activity in Asian patients with systemic lupus erythematosus Sci Rep, 2016-07-25;6(0):29909. 2016-07-25 [PMID: 27453287] (Human) Human
Karta , Maya R, Wickert , Lisa E, Curran , Colleen, Gavala , Monica L, Denlinger , Loren C, Gern , James E, Bertics , Paul J Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages. J Allergy Clin Immunol, 2014-02-14;133(4):1227-30. 2014-02-14 [PMID: 24529411] (ELISA Development (Detection), Human) ELISA Development (Detection) Human
Zaheer R, Wiehler S, Hudy M, Traves S, Pelikan J, Leigh R, Proud D Human rhinovirus-induced ISG15 selectively modulates epithelial antiviral immunity. Mucosal Immunol, 2014-01-22;7(5):1127-38. 2014-01-22 [PMID: 24448099] (ELISA Development (Detection), Human) ELISA Development (Detection) Human
Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62. 2008-03-01 [PMID: 18327985] (Luminex Development, Human) Luminex Development Human
Qui H, Ferrell EP, Nolan N, Phelps BH, Tabibiazar R, Whitney DH, Naelfski EA Fluorescence single-molecule counting assays for high-sensitivity detection of cytokines and chemokines. Clin. Chem., 2007-11-01;53(11):2010-2. 2007-11-01 [PMID: 18030696] (ELISA Development, Human) ELISA Development Human
Pfleger C, Schloot N, ter Veld F Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J. Immunol. Methods, 2007-10-22;329(1):214-8. 2007-10-22 [PMID: 17964594] (Luminex Development, Human) Luminex Development Human
Show All 19 Publications.

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Bioinformatics

Gene Symbol CXCL10