Immunohistochemistry-Paraffin: CNGB3 Antibody [NBP2-75087] - Negative Control showing staining of paraffin embedded Human Retina, with no primary antibody.
Immunohistochemistry-Paraffin: CNGB3 Antibody [NBP2-75087] - (2ug/ml) staining of paraffin embedded Human Retina. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.
Use in Monkey reported in scientific literature (PMID:35024589) .
Packaging, Storage & Formulations
Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
TBS (pH 7.3), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Antigen Affinity-purified
Alternate Names for CNGB3 Antibody
cyclic nucleotide gated channel beta 3
Background
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 . Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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