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Claudin-3 Antibody (385021) [CoraFluor™ 1]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, CyTOF-ready, ICC/IF
Clone
385021
Clonality
Monoclonal
Host
Mouse
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB4620U-100UG
Alexa Fluor 405
FAB4620V-100UG
Alexa Fluor 488
FAB4620G-100UG
Alexa Fluor 532
FAB4620X
Alexa Fluor 594
FAB4620T-100UG
Alexa Fluor 647
FAB4620R-100UG
Alexa Fluor 700
FAB4620N-100UG
Alexa Fluor 750
FAB4620S-100UG
Allophycocyanin
FAB4620A
Allophycocyanin/Cy7
FAB4620APCCY7
Biotin
FAB4620B
DyLight 350
FAB4620D
DyLight 405
FAB4620E
DyLight 488
FAB4620K
DyLight 550
FAB4620L
DyLight 594
FAB4620M
DyLight 650
FAB4620W
DyLight 680
FAB4620Y
DyLight 755
FAB4620Z
Fluorescein
FAB4620F
HRP
FAB4620H
Janelia Fluor 525
FAB4620JF525
Janelia Fluor 549
FAB4620I
Janelia Fluor 635
FAB4620JF635
Janelia Fluor 646
FAB4620J
Janelia Fluor 669
FAB4620JF669
PE/Atto594
FAB4620PEATT594
PE/Cy5.5
FAB4620PECY55
PE/Cy7
FAB4620PECY7
PerCP
FAB4620C
Phycoerythrin
FAB4620P
Unconjugated
MAB4620
mFluor Violet 450 SE
FAB4620MFV450
mFluor Violet 500 SE
FAB4620MFV500
mFluor Violet 610 SE
FAB4620MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB4620
Carrier Free
FAB4620F
Carrier Free
FAB4620P
Carrier Free
MAB4620
Carrier Free
FAB4620A
Carrier Free
MAB4620-SP
Carrier Free
FAB4620V-100UG
Carrier Free
FAB4620U-100UG
Carrier Free
FAB4620T-100UG
Carrier Free
FAB4620S-100UG
Carrier Free
FAB4620R-100UG
Carrier Free
FAB4620N-100UG
Carrier Free
FAB4620G-100UG
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Claudin-3 Antibody (385021) [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Immunogen
HEK293 human embryonic kidney cell line transfected with human Claudin-3
Met1-Val220
Accession # O15551
Specificity
Stains human Claudin-3 transfectants but not irrelevant transfectants.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
CLDN3
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A or G purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for Claudin-3 Antibody (385021) [CoraFluor™ 1]

  • C7orf1
  • claudin 3
  • Claudin3
  • Claudin-3
  • CLDN3
  • Clostridium perfringens enterotoxin receptor 2
  • CPE-R 2
  • CPE-R2
  • CPETR2
  • CPETR2CPE-receptor 2
  • HRVP1
  • Rat ventral prostate.1 protein homolog
  • RVP1
  • ventral prostate.1 protein homolog
  • ventral prostate.1-like protein

Background

The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and variations of Claudin expression may have an important role in transcellular transport through tight junctions. In rat liver, claudin-3 is uniformly expressed, whereas in the pancreas, claudin-3 is expressed in junctions of the duct epithelia and junctions of acinar cells. Claudin-3 binds the peptide toxin Clostridium perfringens enterotoxin (CPE) at the cell surface via the second extracellular loop of claudin-3. The gene encoding human claudin-3 maps to chromosome 7q11.23.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CLDN3