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CHMP4C Antibody

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Orthogonal Strategies: Immunohistochemistry-Paraffin: CHMP4C Antibody [NBP1-81166] - Staining in human small intestine and testis tissues using anti-CHMP4C antibody. Corresponding CHMP4C RNA-seq data are ...read more
Immunohistochemistry-Paraffin: CHMP4C Antibody [NBP1-81166] - Staining of human small intestine shows high expression.
Immunohistochemistry-Paraffin: CHMP4C Antibody [NBP1-81166] - Staining of human testis shows low expression as expected.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

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CHMP4C Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: MSKLGKFFKGGGSSKSRAAPSPQEALVRLRETEEMLGKKQEYLENRIQREIALAKKHGTQN
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CHMP4C
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
CHMP4C Protein (NBP1-81166PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (85%), Rat (84%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for CHMP4C Antibody

  • charged multivesicular body protein 4c
  • CHMP4c
  • chromatin modifying protein 4C
  • Chromatin-modifying protein 4c
  • hSnf7-3
  • hVps32-3
  • MGC22825
  • Shax3
  • SNF7 homolog associated with Alix 3
  • Snf7 homologue associated with Alix 3
  • SNF7-3
  • Vacuolar protein sorting-associated protein 32-3
  • vps32-3
  • VPS32C

Background

CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CHMP4C
Entrez
Uniprot