CFTR Antibody (13-1) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cystic fibrosis transmembrane conductance regulator (CFTR) is a multi-pass transmembrane protein that functions as a chloride channel. CFTR belongs to the ATP-binding cassette (ABC) superfamily. Mutations in CFTR cause the pulmonary disease, cystic fibrosis (CF). Specifically, deletion of phenyalanine at position 508 (DeltaF508-CFTR) results in a folding defect which impairs chloride channel function. The mechanism by which channel dysfunction relates to disease symptoms is a focus of intense research. CFTR dysfunction results in disruption of ion transport and subsequent blockage of airways by secreted mucus. CFTR may also play a role in the skeletal muscle atrophy and dysfunction that characterizes CF. In addition, CFTR-mediated chloride secretion underlies fluid accumulation and cyst growth in autosomal dominant polycystic kidney disease (ADPKD).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Amphibian, Ovine, Xenopus.

We have publications tested in 6 applications: ICC, IHC, IHC-Fr, IHC-P, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using MAB1660	Applications	Species
Zhongyu Liu, Justin D. Anderson, Jennifer Natt, Jennifer S. Guimbellot Culture and Imaging of Human Nasal Epithelial Organoids Journal of Visualized Experiments 1/3/2022 [PMID: 34978285]
Z Liu, JD Anderson, L Deng, S Mackay, J Bailey, L Kersh, SM Rowe, JS Guimbellot Human Nasal Epithelial Organoids for Therapeutic Development in Cystic Fibrosis Genes (Basel), 2020-05-29;11(6):. 2020-05-29 [PMID: 32485957] (ICC, Human)	ICC	Human
Diogo R. Poroca, Noha Amer, Audrey Li, John W. Hanrahan, Valerie M. Chappe Changes in the R‐region interactions depend on phosphorylation and contribute to PKA and PKC regulation of the cystic fibrosis transmembrane conductance regulator chloride channel FASEB BioAdvances 1/1/2020 [PMID: 32123855]
Emily Xia, Yiqian Zhang, Huibi Cao, Jun Li, Rongqi Duan, Jim Hu TALEN-Mediated Gene Targeting for Cystic Fibrosis-Gene Therapy Genes (Basel) 1/11/2019 [PMID: 30641980]
Emily Xia, Rongqi Duan, Fushan Shi, Kyle E. Seigel, Hartmut Grasemann, Jim Hu Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction Molecular Therapy - Nucleic Acids 12/7/2018 [PMID: 30513454]
Z Bozoky, S Ahmadi, T Milman, TH Kim, K Du, M Di Paola, S Pasyk, R Pekhletski, JP Keller, CE Bear, JD Forman-Kay Synergy of cAMP and calcium signaling pathways in CFTR regulation Proc. Natl. Acad. Sci. U.S.A, 2017-02-27;0(0):. 2017-02-27 [PMID: 28242698] (ICC, Human)	ICC	Human
Vina Z. Zinn, Aditi Khatri, Maija I. Mednieks, Arthur R. Hand Localization of cystic fibrosis transmembrane conductance regulator signaling complexes in human salivary gland striated duct cells European Journal of Oral Sciences 6/1/2015 [PMID: 25903037]
Dong Q, Ernst S, Ostedgaard L, Shah V, Ver Heul A, Welsh M, Randak C Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia. J Biol Chem, 2015-04-17;290(22):14140-53. 2015-04-17 [PMID: 25887396] (Western Blot, Human)	Western Blot	Human
Pascale Marcorelles, Gaëlle Friocourt, Arnaud Uguen, Françoise Ledé, Claude Férec, Annie Laquerrière Cystic fibrosis transmembrane conductance regulator protein (CFTR) expression in the developing human brain: comparative immunohistochemical study between patients with normal and mutated CFTR Journal of Histochemistry & Cytochemistry 11/1/2014 [PMID: 25062999]
Yan , Ziying, Keiser , Nicholas, Song , Yi, Deng , Xuefeng, Cheng , Fang, Qiu , Jianming, Engelhardt , John F A novel chimeric adenoassociated virus 2/human bocavirus 1 parvovirus vector efficiently transduces human airway epithelia. Mol Ther, 2013-07-30;21(12):2181-94. 2013-07-30 [PMID: 23896725] (IHC-Fr, Human)	IHC-Fr	Human
Sorio C, Buffelli M, Angiari C, Ettorre M, Johansson J, Vezzalini M, Viviani L, Ricciardi M, Verze G, Assael BM, Melotti P Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis. PLoS ONE, 2011-07-21;6(7):e22212. 2011-07-21 [PMID: 21811577] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Wong AP, Keating A, Lu WY, Duchesneau P, Wang X, Sacher A, Hu J, Waddell TK Identification of a bone marrow-derived epithelial-like population capable of repopulating injured mouse airway epithelium. J. Clin. Invest., 2009-01-26;119(2):336-48. 2009-01-26 [PMID: 19164856] (ICC, Mouse)	ICC	Mouse
Davidson H, McLachlan G, Wilson A, Boyd AC, Doherty A, MacGregor G, Davies L, Painter HA, Coles R, Hyde SC, Gill DR, Amaral MD, Collie DD, Porteous DJ, Penque D Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways. Am. J. Respir. Cell Mol. Biol., 2006-02-23;35(1):72-83. 2006-02-23 [PMID: 16498081] (IHC-Fr, Ovine)	IHC-Fr	Ovine
Basavappa S, Vulapalli SR, Zhang H, Yule D, Coon S, Sundaram U Chloride channels in the small intestinal cell line IEC-18. J. Cell. Physiol., 2005-01-01;202(1):21-31. 2005-01-01 [PMID: 15389550] (ICC, Rat)	ICC	Rat
Koehler DR, Sajjan U, Chow YH, Martin B, Kent G, Tanswell AK, McKerlie C, Forstner JF, Hu J Protection of Cftr knockout mice from acute lung infection by a helper-dependent adenoviral vector expressing Cftr in airway epithelia. Proc. Natl. Acad. Sci. U.S.A., 2003-12-12;100(26):15364-9. 2003-12-12 [PMID: 14673110] (ICC, IHC-P, Human, Mouse)	ICC, IHC-P	Human, Mouse
Willumsen NJ, Amstrup J, Mobjerg N, Jespersen A, Kristensen P, Larsen EH Mitochondria-rich cells as experimental model in studies of epithelial chloride channels. Biochim. Biophys. Acta, 2002-11-13;1566(1):28-43. 2002-11-13 [PMID: 12421535] (IHC-P, Xenopus)	IHC-P	Xenopus
Bagorda A, Guerra L, Di Sole F, Hemle-Kolb C, Cardone RA, Fanelli T, Reshkin SJ, Gisler SM, Murer H, Casavola V Reciprocal protein kinase A regulatory interactions between cystic fibrosis transmembrane conductance regulator and Na+/H+ exchanger isoform 3 in a renal polarized epithelial cell model. J. Biol. Chem., 2002-04-05;277(24):21480-8. 2002-04-05 [PMID: 11937500] (Immunoprecipitation, Amphibian)	Immunoprecipitation	Amphibian
Denning GM, Ostedgaard LS, Cheng SH, Smith AE, Welsh MJ Localization of cystic fibrosis transmembrane conductance regulator in chloride secretory epithelia. J. Clin. Invest., 1992-01-01;89(1):339-49. 1992-01-01 [PMID: 1370301] (ICC, IHC, Human)	ICC, IHC	Human
Show All 18 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	WB	Human	02/10/2015	View Summary Application Western Blot Sample Tested See PMID 21811577 Species Human
	4 reviewed by: Verified Customer	WB	Human	02/10/2015	View Summary Application Western Blot Sample Tested See PMID 21952168 Species Human

Array MAB1660

• CFTR Antibodies
• CFTR ELISA Kit
• CFTR Proteins