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CDX2 Antibody (PCRP-CDX2-1A3) [DyLight 755]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, MA
Clone
PCRP-CDX2-1A3
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 755

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-75759AF350
Alexa Fluor 405
NBP2-75759AF405
Alexa Fluor 488
NBP2-75759AF488
Alexa Fluor 532
NBP2-75759AF532
Alexa Fluor 594
NBP2-75759AF594
Alexa Fluor 647
NBP2-75759AF647
Alexa Fluor 700
NBP2-75759AF700
Alexa Fluor 750
NBP2-75759AF750
Allophycocyanin
NBP2-75759APC
Biotin
NBP2-75759B
CoraFluor 1
NBP2-75759CL1
DyLight 350
NBP2-75759UV
DyLight 405
NBP2-75759V
DyLight 488
NBP2-75759G
DyLight 550
NBP2-75759R
DyLight 594
NBP2-75759DL594
DyLight 650
NBP2-75759C
DyLight 680
NBP2-75759FR
FITC
NBP2-75759F
HRP
NBP2-75759H
Janelia Fluor 525
NBP2-75759JF525
Janelia Fluor 549
NBP2-75759JF549
Janelia Fluor 585
NBP2-75759JF585
Janelia Fluor 635
NBP2-75759JF635
Janelia Fluor 646
NBP2-75759JF646
Janelia Fluor 669
NBP2-75759JF669
PE
NBP2-75759PE
PerCP
NBP2-75759PCP
Unconjugated
NBP2-75758-100ug
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-75758-100ug
Azide and BSA Free
NBP2-75759
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CDX2 Antibody (PCRP-CDX2-1A3) [DyLight 755] Summary

Immunogen
Recombinant human full-length CDX2 protein (Uniprot: Q99626)
Localization
Nuclear
Marker
GI Epithelial Marker
Specificity
The specificity of this monoclonal antibody to its intended target was validated by HuProtTMArray, containing more than 19,000, full-length human proteins. The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CDX2
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Microarray
  • Protein Array
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for CDX2 Antibody (PCRP-CDX2-1A3) [DyLight 755]

  • caudal type homeo box transcription factor 2
  • caudal type homeobox 2
  • Caudal-type homeobox protein 2
  • CDX2
  • CDX3
  • CDX-3
  • CDX3caudal type homeobox transcription factor 2
  • homeobox protein CDX-2

Background

The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear proteins that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. The proteins LMX1 (MIM 600298) and CDX3 are homeodomain proteins that bind an A/T-rich sequence in the insulin promoter and stimulate its transcription (German et al., 1994 [PubMed 7698771]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Cdx1 Antibody -
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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CDX2