Cdc20 Antibody

CDC20 is a WD repeat containing cell cycle-regulator that binds to and activates the ubiquitin-ligase activity of the APC/c (anaphase-promoting complex/cyclosome). APC/c ubiquitinating activity is responsible for the degradation of securin and cyclin B that prompts the onset of anaphase and exit from mitosis. CDC20 has also been reported to form a complex with histone deacetylases and can function as a transcriptional repressor involved in cell cycle arrest. As a regulator of APC/c activity, CDC20 plays a key role in the spindle-assembly checkpoint.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 5 of 5.

Publications using NB100-59828	Applications	Species
Douglas, P, Ye, R Et al. Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but. Mol Cell Biol 2020-06-15 [PMID: 32284347] (WB, Mouse)	WB	Mouse
Zhang X, Chen W, Yin N et al. Regulation of OLC1 protein expression by the anaphase-promoting complex Oncol Lett 2019-01-02 [PMID: 30854039] (WB, Human)	WB	Human
Wang R, Li KM, Zhou CH et al. Cdc20 mediates D-box-dependent degradation of Sp100. Biochem Biophys Res Commun 2011-12-01 [PMID: 22086178]
Badtke MM, Jambal P, Dye WW et al. Unliganded progesterone receptors attenuate taxane-induced breast cancer cell death by modulating the spindle assembly checkpoint Breast Cancer Res Treat 2012-01-01 [PMID: 21340479] (WB, Human)	WB	Human
Di Fiore B, Pines J. How cyclin A destruction escapes the spindle assembly checkpoint. J Cell Biol 2010-08-01 [PMID: 20733051]

Array NB100-59828

• Cdc20 Antibodies
• Cdc20 Lysate
• Cdc20 Proteins