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CD94 Antibody (DX22) [FITC]

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CD94 Antibody (DX22) [FITC] [NB100-64104F] - Vial of FITC conjugated antibody. FITC is optimally excited at 498 nm by the Blue laser (488 nm) and has an emission maximum of 519 nm.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
DX22
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Order Details

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CD94 Antibody (DX22) [FITC] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Immunogen
Natural killer cell line
Specificity
NB100-64104 is specific for human CD94, also known as KLRD1 (Killer cell lectin-like receptor, subfamily D, member 1). CD94 is expressed on natural killer (NK) cells and a subset of T lymphocytes. CD94 is found to associate with NKG2 to form a heterodimer which is involved in the inhibition of cell mediated cytotoxicity against cells bearing appropriate MHC class I allotypes. Clone DX22 is reported to inhibit the binding of CD94 to HLA-E(2) and HLA-G(4).
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
KLRD1
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for CD94 Antibody (DX22) [FITC]

  • CD94 antigen
  • CD94
  • CD94natural killer cells antigen CD94
  • Killer cell lectin-like receptor subfamily D member 1
  • killer cell lectin-like receptor subfamily D, member 1
  • KLRD1
  • KP43
  • NK cell receptor

Background

CD94 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T cells. Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol KLRD1