Human whole blood monocytes were stained with Goat Anti-Human CD300b/LMIR5 Antigen Affinity‑purified Polyclonal Antibody (Catalog # AF2879, filled histogram) or control antibody (Catalog # AB‑108‑C, open ...read more
Mouse myeloma cell line NS0-derived recombinant human CD300b/LMIR5 Ile55-His187 Accession # NP_777552
Specificity
Detects human CD300b/LMIR5 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant human LMIR2 and recombinant mouse LMIR5 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
CD300LB
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for CD300b/LMIR5/CD300LB Antibody [Unconjugated]
CD300 antigen like family member B
CD300 antigen-like family member B
CD300 molecule-like family member b
CD300b antigen
CD300b
CD300LB
CLM7
CLM-7
CLM7IREM3CD300 molecule like family member b
CMRF35A2
CMRF35-A2
CMRF35-like molecule 7
EC 1.13.11.6
EC 6.3.4.3
Gm253
Immune receptor expressed on myeloid cells 3
IREM-3
Leukocyte mono-Ig-like receptor 5
LMIR5
TREM-5
TREM5CD300b
Triggering receptor expressed on myeloid cells 5
Background
CD300b, also known asLMIR5, CLM7 (CMRF-35-like Molecule 7) and TREM5 (Triggering Receptor Expressed on Myeloid cells 5) belongs to a multigene family whose members are closely mapped to a region of human chromosome 17 and mouse chromosome 11. These genes encode type I membrane proteins with a single extracellular Ig-like domain and the proteins are expressed widely in leukocytes. LMIR/CD300 family proteins are immunoregulatory signaling molecules that either have cytoplasmic ITIM motifs or can interact with ITAM motif-bearing molecules through a characteristic transmembrane domain containing positively charged amino acid residues. CD300b/LMIR5 is an ITAM adaptor-associated receptor with a short cytoplasmic region. Human and mouse CD300b/LMIR5 share approximately 45% amino acid sequence identity.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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