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CD27 Ligand/TNFSF7/CD70 Antibody (TAN 1-7) [Janelia Fluor® 525]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications ELISA, Flow, Func, ICC/IF, CyTOF-ready
Clone
TAN 1-7
Clonality
Monoclonal
Host
Rat
Conjugate
Janelia Fluor 525

Order Details

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CD27 Ligand/TNFSF7/CD70 Antibody (TAN 1-7) [Janelia Fluor® 525] Summary

Immunogen
Recombinant mouse CD27 Ligand/TNFSF7/CD70 (extracellular domain, aa residues 41-195)
Specificity
This antibody is a non-depleting mAb that blocks the CD70-CD27 interaction.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
CD70
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • ELISA
  • Flow Cytometry
  • Functional
  • Immunocytochemistry/ Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for CD27 Ligand/TNFSF7/CD70 Antibody (TAN 1-7) [Janelia Fluor® 525]

  • CD27 Ligand
  • CD27-L
  • CD27LCD27 ligand
  • CD27LG
  • CD70 molecule
  • CD70
  • Ki-24 antigen
  • surface antigen CD70
  • TNFSF7
  • TNFSF7CD70 antigen
  • tumor necrosis factor (ligand) superfamily, member 7
  • Tumor necrosis factor ligand superfamily member 7

Background

CD70 is a type II transmembrane protein. It is a member of the TNF superfamily, expressed on activated B cells, activated dendritic cells, and some activated T cells (low levels). CD70 interacts with CD27 to promote T-B cell cross-stimulation and co-stimulate B cell proliferation and immunoglobulin production. Cells expressing CD70 can co-stimulate T cell proliferation and enhance the production of cytokines. The FR70 antibody blocks CD70 binding to CD27.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

FAQs for CD27 Ligand/TNFSF7/CD70 Antibody (NBP2-50150JF525) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CD70