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CCL17/TARC Antibody (54026)

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Recombinant Human CCL17/TARC (Catalog # 364-DN) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CCR4 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Human CCL17/TARC (10 ng/mL) is neutralized (green line) by increasing concentrations of Human CCL17/TARC Monoclonal Antibody (Catalog # MAB364). The ND50 is typically 0.4-2.0 µg/mL.
Recombinant Human CCL17/TARC (Catalog # 364-DN) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CCR4 in a dose-dependent manner (orange line). The amount of cells that migrated through to ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications B/N, ELISA(Cap)
Clone
54026
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB364-SP
Carrier Free
MAB364-500
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CCL17/TARC Antibody (54026) Summary

Immunogen
E. coli-derived recombinant human CCL17/TARC
Ala24-Ser94
Accession # Q92583.1
Specificity
Detects human CCL17/TARC in ELISAs. Does not cross-react with recombinant human (rh) CCL2, 3, 4, 5, 7, 8, 11, 13, 16, 18, 19, 20, 21, 22, 23, 24, 25, rmCCL2, 3, 4, 5, 7, 9/10/MIP-1 gamma , 11, 12, 21, 22, 25, or rrCCL20.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CCL17
Purity Statement
Protein A or G purified from ascites
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
  • Neutralization 0.4-2.0 ug/mL
Application Notes
ELISA Detection: Human CCL17/TARC Biotinylated Antibody (Catalog number BAF364)
Standard: Recombinant Human CCL17/TARC (Catalog number 364-DN)
Publications
Read Publications using
MAB364 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CCL17/TARC Antibody (54026)

  • ABCD-2
  • CC chemokine TARC
  • C-C motif chemokine 17
  • CCL17
  • chemokine (C-C motif) ligand 17
  • MGC138273
  • SCYA17
  • SCYA17MGC138271
  • small inducible cytokine subfamily A (Cys-Cys), member 17
  • Small-inducible cytokine A17
  • T cell-directed CC chemokine
  • TARC
  • TARCA-152E5.3
  • Thymus and activation-regulated chemokine

Background

CCL17 is a novel CC chemokine identified using a signal sequence trap method. CCL17 cDNA encodes a highly basic 94 amino acid (aa)residue precursor protein with a 23 aa residue signal peptide that is cleaved to generate the 71 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24-29% amino acid sequence identity with RANTES, MIP-1 alpha , MIP-1 beta , MCP-1, MCP-2, MCP-3, and I-309. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. CCL17 is constitutively expressed in thymus, and at a lower level in lung, colon, and small intestine. CCL17 is also transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant CCL17 has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL17 was identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells.

  1. Imai, T. et al. (1997) J. Biol. Chem. 272:15036.
  2. Imai, T. et al. (1996) J. Biol. Chem. 271:21514.
  3. Nomiyama, H. et al. (1997) Genomics 40:211.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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CCL17/TARC
Antibody (54026)
MAB364
CCL17/TARC Antibody (54026)
Species: Hu
Applications: B/N, ELISA(Cap)

Publications for CCL17/TARC Antibody (MAB364)(11)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Bioassay, ELISA Development, Neutralization.


Filter By Application
Bioassay
(1)
ELISA Development
(4)
Neutralization
(3)
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Human
(8)
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Showing Publications 1 - 10 of 11. Show All 11 Publications.
Publications using MAB364 Applications Species
Elizabeth L. Magnotti, Leo Li-Ying Chan, Quan Zhu, Wayne A. Marasco A high-throughput chemotaxis detection method for CCR4+ T cell migration inhibition using image cytometry Journal of Immunological Methods 2020-04-01 [PMID: 31958449]
Yingying Wang, Xiaoling Weng, Luoyang Wang, Mingang Hao, Yue Li, Lidan Hou et al. HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk Journal of Clinical Investigation 2018-10-22 [PMID: 30204129]
Weiwei He, Ge Bai, Huihao Zhou, Na Wei, Nicholas M. White, Janelle Lauer et al. CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase Nature 2015-10-29 [PMID: 26503042]
Paantjens AW, van de Graaf EA, Kwakkel-van Erp JM, Hoefnagel T, van Kessel DA, van den Bosch JM, Otten HG Lung transplantation affects expression of the chemokine receptor type 4 on specific T cell subsets. Clin. Exp. Immunol., 2011-10-01;166(1):103-9. 2011-10-01 [PMID: 21910727] (ELISA Development, Human) ELISA Development Human
Mizukami Y, Kono K, Kawaguchi Y, Akaike H, Kamimura K, Sugai H, Fujii H CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer. Int. J. Cancer, 2008-05-15;122(10):2286-93. 2008-05-15 [PMID: 18224687] (Bioassay, Human) Bioassay Human
Haas J, Schopp L, Storch-Hagenlocher B, Fritzsching B, Jacobi C, Milkova L, Fritz B, Schwarz A, Suri-Payer E, Hensel M, Wildemann B Specific recruitment of regulatory T cells into the CSF in lymphomatous and carcinomatous meningitis. Blood, 2007-10-29;111(2):761-6. 2007-10-29 [PMID: 17967942] (Neutralization, Human) Neutralization Human
Liu LY, Bates ME, Jarjour NN, Busse WW, Bertics PJ, Kelly EA Generation of Th1 and Th2 chemokines by human eosinophils: evidence for a critical role of TNF-alpha. J. Immunol., 2007-10-01;179(7):4840-8. 2007-10-01 [PMID: 17878383] (ELISA Development, Human) ELISA Development Human
Vestergaard C, Johansen C, Christensen U, Just H, Hohwy T, Deleuran M TARC augments TNF-alpha-induced CTACK production in keratinocytes. Exp. Dermatol., 2004-09-01;13(9):551-7. 2004-09-01 [PMID: 15335355] (Neutralization, Human) Neutralization Human
Curiel , Tyler J, Coukos , George, Zou , Linhua, Alvarez , Xavier, Cheng , Pui, Mottram , Peter, Evdemon-Hogan , Melina, Conejo-Garcia , Jose R, Zhang , Lin, Burow , Matthew, Zhu , Yun, Wei , Shuang, Kryczek , Ilona, Daniel , Ben, Gordon , Alan, Myers , Leann, Lackner , Andrew, Disis , Mary L, Knutson , Keith L, Chen , Lieping, Zou , Weiping Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med, 2004-08-22;10(9):942-9. 2004-08-22 [PMID: 15322536] (Neutralization, Human) Neutralization Human
Liu L, Jarjour NN, Busse WW, Kelly EA Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma. Am. J. Respir. Crit. Care Med., 2004-03-04;169(10):1118-24. 2004-03-04 [PMID: 15001464] (ELISA Development, Human) ELISA Development Human
Show All 11 Publications.

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Bioinformatics

Gene Symbol CCL17
Uniprot