CCL11/Eotaxin Antibody (43911) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCL11 is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. Microsequencing of the purified protein revealed the guinea pig CCL11 to be a member of the beta (CC) chemokine family of inflammatory and immunoregulatory cytokines. cDNA clones for guinea pig, mouse, and human CCL11 have been isolated. Human CCL11 cDNA encodes a 97 amino acid residue precursor protein from which the amino-terminal 23 amino acid residues are cleaved to generate the 74 amino acid residue mature human CCL11. At the protein sequence level, mature human CCL11 is approximately 60% identical to mature mouse and guinea pig CCL11. In addition, human CCL11 also shows high amino acid sequence identity to human MCP-1, 2, and 3. Human CCL11 is chemotactic for eosinophils, but not mononuclear cells or neutrophils. The CC chemokine receptor 3 (CCR3) has now been identified to be a specific human CCL11 receptor (1-3). CCR3 has also been shown to serve as a cofactor for a restricted subset of primary HIV viruses and binding of CCL11 to CCR3 inhibited infection by the HIV isolates (4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ELISA Development, IHC-Fr, IHC-P, Neutralization.

Showing Publications 1 - 10 of 10.

Publications using MAB320	Applications	Species
Rump L, Mattey D, Kehoe O, Middleton J An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. Cytokine, 2017-09-01;97(0):133-140. 2017-09-01 [PMID: 28648867] (IHC-Fr, Human)	IHC-Fr	Human
Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Despres S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature, 2011-08-31;477(7362):90-4. 2011-08-31 [PMID: 21886162] (Neutralization, Mouse)	Neutralization	Mouse
Miyagaki T, Sugaya M, Fujita H Eotaxins and CCR3 interaction regulates the Th2 environment of cutaneous T-cell lymphoma. J. Invest. Dermatol., 2010-05-27;130(9):2304-11. 2010-05-27 [PMID: 20505746] (IHC-P, Human)	IHC-P	Human
Lena Uller, Cecilia Ahlström Ahlström Emanuelsson, Morgan Andersson, Jonas S Erjefält, Lennart Greiff, Carl G Persson Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitis Respiratory Research 12/1/2010 [PMID: 20459697]
Osei-Kumah A, Smith R, Clifton VL Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma. Cytokine, 2008-07-17;43(2):187-93. 2008-07-17 [PMID: 18639465] (ELISA Development, Human)	ELISA Development	Human
Miller M, Ramsdell J, Friedman PJ, Cho JY, Renvall M, Broide DH Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema. J. Allergy Clin. Immunol., 2007-11-01;120(5):1118-25. 2007-11-01 [PMID: 17983873] (IHC-P, Human)	IHC-P	Human
Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck LA, Lamkhioued B Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin. Immunol., 2006-06-16;120(2):220-31. 2006-06-16 [PMID: 16782408] (ELISA Development, Neutralization, Human)	ELISA Development, Neutralization	Human
Puxeddu I, Bader R, Piliponsky AM, Reich R, Levi-Schaffer F, Berkman N The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts. J. Allergy Clin. Immunol., 2005-12-02;117(1):103-10. 2005-12-02 [PMID: 16387592] (Neutralization, Human)	Neutralization	Human
Hajnicka V, Vancova I, Kocakova P, Slovak M, Gasperik J, Slavikova M, Hails RS, Labuda M, Nuttall PA Manipulation of host cytokine network by ticks: a potential gateway for pathogen transmission. Parasitology, 2005-03-01;130(0):333-42. 2005-03-01 [PMID: 15796016] (ELISA Development, Human)	ELISA Development	Human
Bottcher MF, Jenmalm MC, Bjorksten B, Garofalo RP Chemoattractant factors in breast milk from allergic and nonallergic mothers. Pediatr. Res., 2000-05-01;47(5):592-7. 2000-05-01 [PMID: 10813582] (ELISA Development, Human)	ELISA Development	Human

Array MAB320

• CCL11/Eotaxin Antibodies
• CCL11/Eotaxin ELISA Kits
• CCL11/Eotaxin Lysate
• CCL11/Eotaxin Proteins
• CCL11/Eotaxin ELISAs
• CCL11/Eotaxin Proteins and Enzymes