Caspase-10/FLICE2 Antibody (63131)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Caspase-10 (Cysteine-aspartic acid protease 10, FLICE2 and Mch4) is a 28-29 kDa member of the peptidase C14A family of enzymes. It is widely expressed, being found in blood and epithelial cells. Caspase-10 appears to be an initiator caspase that acts on Pro-Caspases-3, -4, -6, -7, and -9. Human Pro-Caspase-10a is a 59 kDa, 521 amino acid (aa) protein. It contains two N-terminal death domains. Cleavage generates p43 plus the small mature p12 subunit. Cleavage of p43  generates a prodomain p25 and large mature p17 subunit. P17 and p12 noncovalently associate to form a 29 kDa mature heterodimer. There are at least four isoform variants. There is no apparent mouse Casp-10 gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 2 of 2.

Publications using MAB834	Applications	Species
Goepel F, Weinmann P, Schymeinsky J, Walzog B Identification of caspase-10 in human neutrophils and its role in spontaneous apoptosis. J. Leukoc. Biol., 2004-02-03;75(5):836-43. 2004-02-03 [PMID: 14761933] (Western Blot, Human)	Western Blot	Human
Qiu J, Whalen MJ, Lowenstein P, Fiskum G, Fahy B, Darwish R, Aarabi B, Yuan J, Moskowitz MA Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans. J. Neurosci., 2002-05-01;22(9):3504-11. 2002-05-01 [PMID: 11978827] (Western Blot, Mouse)	Western Blot	Mouse

Array MAB834

• Caspase-10/FLICE2 Antibodies
• Caspase-10/FLICE2 ELISA Kits
• Caspase-10/FLICE2 Protein
• Caspase-10/FLICE2 Proteins and Enzyme