Reactivity | HuSpecies Glossary |
Applications | WB, ELISA, ICC/IF, IHC |
Clonality | Polyclonal |
Host | Rabbit |
Conjugate | DyLight 488 |
Immunogen | Caspase-1 Antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Caspase-1. The immunogen is located within the last 50 amino acids of Caspase-1 (NP_001244047.1, NP_001244048.1, NP_150635.1, NP_150636.1). Amino Acid Squence: SFEQPDGRAQMPTTER |
Specificity | Depending on cell lines or tissues used, other cleavage products may be observed. |
Isotype | IgG |
Clonality | Polyclonal |
Host | Rabbit |
Gene | CASP1 |
Purity | Peptide affinity purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Application Notes | Optimal dilution of this antibody should be experimentally determined. |
Storage | Store at 4C in the dark. |
Buffer | 50mM Sodium Borate |
Preservative | 0.05% Sodium Azide |
Purity | Peptide affinity purified |
Secondary Antibodies |
Isotype Controls |
Research Areas for Caspase-1 Antibody (NBP1-76605G)Find related products by research area.
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The NLRP3 Inflammasome: Macrophage Activator & Pathology Driver By Victoria Osinski, PhDWhat is the NLRP3 Inflammasome?With its critical role in innate immunity, the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome ... Read full blog post. |
Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T... Read full blog post. |
The inflammasome: an inflammation-initiating machine, Novus Biologicals By Stephanie Melchor The inflammasome is a large, multimeric protein complex found primarily in innate immune cells, which are white blood cells that can attack a wide range of pathogenic threats. Three main elements ... Read full blog post. |
NLRP3/NALP3 - Sensing and responding to pathogen infection The inflammasome is a multi protein complex that is an important component of the innate immune response. The inflammasome is able to sense and respond to pathogen infections by recognizing pathogen-associated molecular patterns and mediating the ... Read full blog post. |
Caspase 10 - an initiator caspase in the extrinsic death receptor pathway Apoptosis, also called programmed cell death, is an essential process in development and disease. The signaling networks that carry out apoptosis is consists of a series of endoproteases called caspases which are synthesized as inactive zymogens. ... Read full blog post. |
Caspase 7 - A key effector of the apoptotic pathway Caspase-7 is an effector caspase with important roles in mediating cell death signaling. As an effector caspase, caspase-7 is cleaved and activated by initiator caspases such as caspase-1 (1). Like other caspase family proteins, caspase-7 contains a... Read full blog post. |
Caspase 1 - activating innate immune responses following infection or injury Caspase-1 is an enzyme involved in the conversion of interleukin-1 into its active secreted form. Interleukin-1 mediates inflammatory responses during infection and disease. Caspase-1 is recruited to and activated by the inflammasome complex (1). Un... Read full blog post. |
Caspase-4 - a human protease with roles in inflammation and immunity Caspases are a family of cysteine-aspartic acid proteases that cleave caspase proenzymes as well as other protein substrates. Caspases are well known for their role in apoptosis, but they also play a significant role in other cellular processes inc... Read full blog post. |
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Gene Symbol | CASP1 |