CART/CARTPT Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CART, also known as cocaine and amphetamine-regulated transcript, is a 10 kDa secreted polypeptide produced by neuronal cell types in a variety of locations. In human, the molecule is synthesized as a 116 amino acid (aa) precursor with a 27 aa signal sequence an 89 aa mature segment. There are six C-terminal cysteines that form three intrachain disulfide bonds, and the potential exists for both sulfation and phosphorylation in the N-terminal region. There are numerous monobasic and dibasic sites for enzyme cleavage, and multiple, presumably proteolytically-generated short forms are known to exist. These include a 5K, 48 aa peptide (CART 42‑89), and a 4.3K, 40 aa peptide (CART 49-89). Human CART is 98% aa identical to both moyuse and rat CART (1‑89). Although CART suppresses feeding and increases pain tolerance, there would appear to be differences between the various forms of CART on other functions. In addition, anatomical location is associated with differing lengths of CART. For example, 89 aa and 79 aa forms are found in the adrenal, while 48 aa and 44 aa forms are found in the hypothalamus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 2 applications: ICC, IHC.

Showing Publications 1 - 6 of 6.

Publications using AF163	Applications	Species
Kobori, N;Moore, AN;Redell, JB;Dash, PK; Caudal DMN neurons innervate the spleen and release CART peptide to regulate neuroimmune function Journal of neuroinflammation 7/4/2023 [PMID: 37403174]
Topilko T, Diaz SL, Pacheco CM et al. Edinger-Westphal peptidergic neurons enable maternal preparatory nesting Neuron 2/1/2022 [PMID: 35123655]
Lyla Kelley, Silvanna Verlezza, Hong Long, Mary Loka, Claire-Dominique Walker Increased Hypothalamic Projections to the Lateral Hypothalamus and Responses to Leptin in Rat Neonates From High Fat Fed Mothers Frontiers in Neuroscience 1/31/2020 [PMID: 32082105]
Laurent Gautron Levels of Cocaine- and Amphetamine-Regulated Transcript in Vagal Afferents in the Mouse Are Unaltered in Response to Metabolic Challenges eNeuro, 2016-10-05;3(5):. 10/5/2016 [PMID: 27822503]
Ye Long, Andrea S. Bordt, Weiley S. Liu, Elizabeth P. Davis, Stephen J. Lee, Luke Tseng et al. Wide-field diffuse amacrine cells in the monkey retina contain immunoreactive Cocaine- and Amphetamine-Regulated Transcript (CART) Peptides 10/1/2016 [PMID: 27568514]
Cortes-Campos C, Elizondo R, Carril C, Martinez F, Boric K, Nualart F, Garcia-Robles M MCT2 expression and lactate influx in anorexigenic and orexigenic neurons of the arcuate nucleus. PLoS ONE, 2013-04-26;8(4):e62532. 2013-04-26 [PMID: 23638108] (ICC, IHC, Rat)	ICC, IHC	Rat

Array AF163

• CART/CARTPT Antibodies
• CART/CARTPT ELISA Kit
• CART/CARTPT Lysate
• CART/CARTPT Protein
• CART/CARTPT Proteins and Enzyme