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Cannabinoid R2/CB2/CNR2 Antibody (352110R) [CoraFluor™ 1]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready
Clone
352110R
Clonality
Monoclonal
Host
Mouse
Conjugate
CoraFluor 1

Order Details

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Cannabinoid R2/CB2/CNR2 Antibody (352110R) [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Additional Information
Recombinant Monoclonal Antibody.
Immunogen
Human embryonic kidney cell line HEK293-derived transfected with human Cannabinoid R2/CB2/CNR2
Met1-Cys360
Accession # NP_001832
Specificity
Detects human Cannabinoid R2/CB2/CNR2 in HEK293 human cell line transfected with human Cannabinoid R2/CB2/CNR2 and not Cannabinoid R1/CB1/CNR1 transfectants in flow cytometry.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A or G purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for Cannabinoid R2/CB2/CNR2 Antibody (352110R) [CoraFluor™ 1]

  • Cannabinoid R2
  • cannabinoid receptor 2 (macrophage)
  • CannabinoidR2
  • CB-2
  • CB2cannabinoid receptor 2
  • CB2R
  • CNR2
  • CX5
  • CX5testis-dominant CNR2 isoform CB2
  • hCB2

Background

Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P / Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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