Canine IL-4 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-4 (Interleukin-4) is a cytokine that is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. The type I receptor for IL-4, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R? and the common ? chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and -21). The type II receptor on nonhematopoietic cells consists of IL-4 R? and IL-13 R?1. The type II receptor also transduces IL-13 mediated signals.

We have publications tested in 2 confirmed species: Canine, Ferret.

Showing Publications 1 - 10 of 10.

Publications using DY754	Applications	Species
Costa, SF;Soares, MF;Poleto Bragato, J;Dos Santos, MO;Rebech, GT;de Freitas, JH;de Lima, VMF; MicroRNA-194 regulates parasitic load and IL-1?-dependent nitric oxide production in the peripheral blood mononuclear cells of dogs with leishmaniasis PLoS neglected tropical diseases 2024-01-01 [PMID: 38241360] (Canine)		Canine
Zhao, J;Sun, Y;Sui, P;Pan, H;Shi, Y;Chen, J;Zhang, H;Wang, X;Tao, R;Liu, M;Sun, D;Zheng, J; DNA Vaccine Co-Expressing Hemagglutinin and IFN-? Provides Partial Protection to Ferrets against Lethal Challenge with Canine Distemper Virus Viruses 2023-09-04 [PMID: 37766279] (Ferret)		Ferret
M Pelst, C Höbart, H de Rooster, B Devriendt, E Cox Immortalised canine buccal epithelial cells' CXCL8 secretion is affected by allergen extracts, Toll-like receptor ligands, IL-17A and calcitriol Veterinary research, 2022-09-13;53(1):72. 2022-09-13 [PMID: 36100942] (Canine)		Canine
S Kim, YS Hyun, HT Park, MK Shin, HS Yoo Mycobacterium intracellulare induces a Th17 immune response via M1-like macrophage polarization in canine peripheral blood mononuclear cells Scientific Reports, 2022-07-12;12(1):11818. 2022-07-12 [PMID: 35821058] (Canine)		Canine
RM Gorczynski, T Maqbool, G Hoffmann Combined IMIG and Immune Ig Attenuate Allergic Responses in Beagle Dogs J Immunol Res, 2020-04-21;2020(0):2061609. 2020-04-21 [PMID: 32377529] (Canine)		Canine
A Kathrani, E Hall A preliminary study assessing cytokine production following ex vivo stimulation of whole blood with diet in dogs with chronic enteropathy BMC Vet. Res., 2019-06-04;15(1):185. 2019-06-04 [PMID: 31164117] (Canine)		Canine
AB Wardini, LH Pinto-da-S, NR Nadaes, MT Nascimento, BM Roatt, AB Reis, KF Viana, RC Giunchetti, EM Saraiva Neutrophil properties in healthy and Leishmania infantum-naturally infected dogs Sci Rep, 2019-04-18;9(1):6247. 2019-04-18 [PMID: 31000764] (Canine)		Canine
KL Oliveira S, V Marin Chik, G Luvizotto, AA Correa Lea, BF de Almeida, F De Rezende, PSP Dos Santos, G Fabrino Ma, VMF De Lima PD-1 and PD-L1 regulate cellular immunity in canine visceral leishmaniasis Comp. Immunol. Microbiol. Infect. Dis., 2018-12-14;62(0):76-87. 2018-12-14 [PMID: 30711051] (Canine)		Canine
LG Ferreira, M Endrighi, KG Lisenko, MRD de Oliveir, MR Damasceno, JA Claudino, PG Gutierres, AP Peconick, FMOB Saad, MG Zangeronim Oat beta-glucan as a dietary supplement for dogs PLoS ONE, 2018-07-31;13(7):e0201133. 2018-07-31 [PMID: 30063762] (Canine)		Canine
Figueiredo M, Deoti B, Amorim I, Pinto A, Moraes A, Carvalho C, da Silva S, de Assis A, de Faria A, Tafuri W Expression of regulatory T cells in jejunum, colon, and cervical and mesenteric lymph nodes of dogs naturally infected with Leishmania infantum. Infect Immun, 2014-06-16;82(9):3704-12. 2014-06-16 [PMID: 24935975] (Canine)		Canine

Array DY754

• IL-4 Antibodies
• IL-4 ELISA Kits
• IL-4 Kit
• IL-4 Proteins
• IL-4 Proteins and Enzymes
• IL-4 ELISAs