beta-Arrestin 2 Antibody

Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain. The process of converting light to an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentrations causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin's activity is believed to be shut off by its phosphorylation followed by binding of the soluble protein arrestin. Arrestins are cytosolic proteins that are involved in G protein-coupled receptor (GPCR) desensitization. Arrestin binding to activated GPCRs is phosphorylation dependent and, once bound, uncouple the GPCR from the associated heterotrimeric G proteins. There are currently 4 known mammalian isoforms, beta-arrestin1 (arrestin2), beta-arrestin2 (arrestin3), visual arrestin (arrestin1), and cone arrestin. The beta- isoforms are ubiquitously expressed and are known to interact with acetylcholine and adrenergic receptors. Visual and cone arrestins are found to interact directly with transducin.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IP.

Showing Publications 1 - 2 of 2.

Publications using NB300-587	Applications	Species
Pierre-Marie Boutanquoi, Amira Sayed Khan, Lidia Cabeza, Lucas Jantzen, Thomas Gautier, Semen Yesylevskyy, Christophe Ramseyer, David Masson, Vincent Van Waes, Aziz Hichami, Naim Akhtar Khan A novel fatty acid analogue triggers CD36–GPR120 interaction and exerts anti-inflammatory action in endotoxemia Cellular and Molecular Life Sciences 2024-04-10 [PMID: 38598021]
St-Pierre A Mapping of the Akt and Beta-arrestin Interface for Drug Development Thesis (IP, Human)	IP	Human

Array NB300-587

• beta-Arrestin 2 Antibodies
• beta-Arrestin 2 ELISA Kit
• beta-Arrestin 2 Proteins