beta-Arrestin 2 Antibody (4D2)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using H00000409-M06	Applications	Species
Ahn KH, Mahmoud MM, Shim JY, Kendall DA. Distinct roles of beta-arrestin 1 and beta-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor one (CB1). J Biol Chem 2013-02-28 [PMID: 23449980] (WB, Human)	WB	Human
Wang WC, Schillinger RM, Malone MM, Liggett S. Paradoxical attenuation of B2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase Am J Physiol Lung Cell Mol Physiol 2011-03-01 [PMID: 21131397] (WB, Mouse)	WB	Mouse

Array H00000409-M06

• beta-Arrestin 2 Antibodies
• beta-Arrestin 2 ELISA Kit
• beta-Arrestin 2 Proteins