ATF4 Antibody (2B3)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 8 of 8.

Publications using H00000468-M01	Applications	Species
Zhou B, Lu Q, Liu J et al. Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway. Int J Biol Sci. 2019-07-21 [PMID: 31523192]
Di Benedetto A, Posa F, De Maria S et al. Polydatin, Natural Precursor of Resveratrol, Promotes Osteogenic Differentiation of Mesenchymal Stem Cells. Int J Med Sci 2018-06-13 [PMID: 30008608]
Wang L, Wang X, Zhang S et al. A Protective Role of Heme-Regulated eIF2alpha kinase in Cadmium-Induced Toxicity in Erythroid Cells. Food Chem Toxicol. 2013-10-22 [PMID: 24161693]
Ghemrawi R, Pooya S, Lorentz S et al. Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1. Cell Death Dis. 2012-12-13 [PMID: 23519122]
Wang X, Guo B, Li Q et al. miR-214 targets ATF4 to inhibit bone formation Nat Med 2012-12-09 [PMID: 23223004] (WB, Mouse)	WB	Mouse
Suragani RN, Zachariah RS, Velazquez JG et al. Heme-regulated eIF2alpha kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis. Blood. 2012-04-12 [PMID: 22498744]
Cole BK, Kuhn NS, Green-Mitchell SM et al. 12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response. Am J Physiol Endocrinol Metab. 2012-01-03 [PMID: 22215650]
Meister S, Frey B, Lang VR et al. Calcium Channel Blocker Verapamil Enhances Endoplasmic Reticulum Stress and Cell Death Induced by Proteasome Inhibition in Myeloma Cells. Neoplasia. 2010-07-01 [PMID: 20651984]

Array H00000468-M01

• ATF4 Antibodies
• ATF4 Antibody Pair
• ATF4 ELISA Kit
• ATF4 Protein