APRIN Antibody

Pds5B is a cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. It plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: KD, WB.

Showing Publications 1 - 5 of 5.

Publications using NB100-755	Applications	Species
Bass TE, Fleenor DE, Burrell PE, Kastan MB ATM Regulation of the Cohesin Complex is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double Strand Breaks Molecular cancer research : MCR 2022-12-05 [PMID: 36469004]
Martino J, Brunette GJ, Barroso-Gonzalez J The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination Nucleic Acids Res 2019-10-31 [PMID: 31665741]
Wagner K, Kunz K, Piller T et al. The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics Cell Rep 2019-10-08 [PMID: 31597105] (WB, KD, Human)	WB, KD	Human
Carvajal-Maldonado D, Byrum AK, Jackson J et al. Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing Nucleic Acids Res. 2018-06-18 [PMID: 29917110] (WB, Human)	WB	Human
Brough R, Bajrami I, Vatcheva R et al. APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer. EMBO J 2012-01-01 [PMID: 22293751]

Array NB100-755

• APRIN Antibodies
• APRIN Proteins