ApoE4 Antibody (4E4) [FITC]

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Apolipoprotein E has three isoforms namely ApoE2, ApoE3, and ApoE4 that differ from each other by single amino acid interchanges at residues 130/176, and ApoE4 is an isoforms which contains arginine at 130 and 176 locations. ApoE4 is mainly synthesized in liver and brain, and is widely expressed in other tissues also. ApoE4 functions have been linked to neuronal plasticity, synaptogenesis etc. and ApoE4 expressing subjects have reduced capacity for synaptic plasticity, increased amyloid-beta deposition, and early onset of Alzheimer's disease (AD). ApoE4 is also linked to progression/poor clinical outcomes in TBI (traumatic brain injury), multiple sclerosis, stroke, frontotemporal dementia, and Parkinson's disease. The neuropathological effects of apoE4 includes impaired neurite outgrowth, cytoskeletal disruption/hyperphosphorylation of tau, neuronal mitochondrial dysfunction, impaired synaptogenesis, increased amyloid beta production as well as clearance/deposition, increased lysosomal leakage and neuronal apoptosis, cerebral neuropathology and impaired learning and memory.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP1-49529F

• ApoE4 Antibodies