Aiolos/IKZF3 Antibody (OTI7E11)

IKZF3 encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NBP2-46048	Applications	Species
Wu J, Wang X, Zhang M et al. RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering Effect Cells 2023-08-03 [PMID: 37566072]
Wu J, Chu E, Paul B, Kang Y Mechanistic Studies and a Retrospective Cohort Study: The Interaction between PPAR Agonists and Immunomodulatory Agents in Multiple Myeloma Cancers 2022-10-27 [PMID: 36358696] (WB, Human)	WB	Human
Sha Y, Wu J, Paul B et al. PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo Cancer letters 2022-07-21 [PMID: 35872263]

Array NBP2-46048

• Aiolos/IKZF3 Antibodies
• Aiolos/IKZF3 Lysate
• Aiolos/IKZF3 Proteins