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AG-2/AGR2 Antibody [FITC]

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Product Details

Summary
Reactivity Hu, Mu, BvSpecies Glossary
Applications IHC, ICC/IF (-)
Clonality
Polyclonal
Host
Rabbit
Conjugate
FITC

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-05933AF350
Alexa Fluor 405
NBP1-05933AF405
Alexa Fluor 488
NBP1-05933AF488
Alexa Fluor 532
NBP1-05933AF532
Alexa Fluor 594
NBP1-05933AF594
Alexa Fluor 647
NBP1-05933AF647
Alexa Fluor 700
NBP1-05933AF700
Alexa Fluor 750
NBP1-05933AF750
Allophycocyanin
NBP1-05933APC
Biotin
NBP1-05933B
CoraFluor 1
NBP1-05933CL1
DyLight 350
NBP1-05933UV
DyLight 405
NBP1-05933V
DyLight 488
NBP1-05933G
DyLight 550
NBP1-05933R
DyLight 594
NBP1-05933DL594
DyLight 650
NBP1-05933C
DyLight 680
NBP1-05933FR
DyLight 755
NBP1-05933IR
HRP
NBP1-05933H
Janelia Fluor 525
NBP1-05933JF525
Janelia Fluor 549
NBP1-05933JF549
Janelia Fluor 635
NBP1-05933JF635
Janelia Fluor 646
NBP1-05933JF646
Janelia Fluor 669
NBP1-05933JF669
PE
NBP1-05933PE
PerCP
NBP1-05933PCP
Unconjugated
NBP1-05933
mFluor Violet 450 SE
NBP1-05933MFV450
mFluor Violet 500 SE
NBP1-05933MFV500
mFluor Violet 610 SE
NBP1-05933MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-05933
BSA Free
NBP1-05933SS
BSA Free
NBP1-05933
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AG-2/AGR2 Antibody [FITC] Summary

Immunogen
Synthetic peptide made to an internal portion of human AGR2 (within residues 50-100). [Swiss-Prot# O95994]
Localization
Secreted
Predicted Species
Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AGR2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:100-1:300
  • Immunohistochemistry-Paraffin 1:100-1:300
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: bovine (100% ).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for AG-2/AGR2 Antibody [FITC]

  • AG2
  • AG-2
  • AG2member 17
  • AGR2
  • anterior gradient 2 homolog (Xenopus laevis)
  • anterior gradient homolog 2 (Xenopus laevis)
  • GOB-4
  • hAG-2
  • HPC8
  • PDIA17
  • secreted cement gland homolog

Background

Originally discovered in Xenopus laevis wherein it plays a role during early neural development, AGR2 (anterior gradient protein 2 homolog) is now known as a member of protein disulfide isomerase (PDI) family of ER-resident proteins which is expressed in a variety of normal as well as transformed epithelial tissues. AGR2 has been implicated in the folding of proteins as a chaperone protein. It interacts with LYPD3, DAG1 (alphaDAG1) and MUC2 (disulfide-linked), and is essential for MUC2 translation as well as secretion. AGR2 plays a key role in the production of mucus by intestinal cells and has also been suggested to be a proto-oncogene that may involve in cellular migration, differentiation and growth. Differential expression of AGR2 was first found in estrogen receptor (ER)-positive breast cancer cell lines and subsequently, elevated AGR2 levels have been seen in subsets of other cancers also wherein its upregulation enhances classical hallmarks of cancer such as metastasis, invasion, colony formation, and proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol AGR2