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Acetylcholinesterase/ACHE Antibody (HR2) [DyLight 650]

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Product Details

Summary
Reactivity Hu, Bv, Fe, Rb, Mu(-), Rt(-)Species Glossary
Applications ELISA, ICC/IF, IHC, IP
Clone
HR2
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 650

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Acetylcholinesterase/ACHE Antibody (HR2) [DyLight 650] Summary

Immunogen
Purified human cerebellar acetylcholinesterase.
Localization
Cell Membrane and Secreted
Marker
Early Neuronal Development Marker
Specificity
This antibody does not detect butyrylcholinesterase (BChE).
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
ACHE
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

No cross-reactivity with Frog.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Acetylcholinesterase/ACHE Antibody (HR2) [DyLight 650]

  • acetylcholinesterase (Yt blood group)
  • Acetylcholinesterase
  • ACHE
  • apoptosis-related acetylcholinesterase
  • ARACHE
  • EC 3.1.1
  • EC 3.1.1.7
  • N-ACHE
  • Yt blood group
  • YT

Background

Cholinergic neurotransmission occurs in motor, autonomic and central nervous synapses and requires very rapid inactivation of its transmitter, acetylcholine (ACh). Acetylcholinesterase (AChE) rapidly hydrolyzes ACh to acetate and choline, thereby inactivating it. AChE is found in the neuromuscular junction anchored to the basal lamina which runs between the nerve terminal and muscle membrane. AChE is also found outside the nervous and neuromuscular system in blood, lymph, germ and liver cells suggesting a role for AChE not related to cholinergic transmission. Another less specific cholinesterase, butyrylcholinesterase (BChE), seems to contribute to the regulation of the ACh concentration in the synaptic cleft.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Video Protocols

ICC/IF Video Protocol

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Bioinformatics

Gene Symbol ACHE