Home » 4-1BB/TNFRSF9/CD137 » 4-1BB/TNFRSF9/CD137 Antibodies » 4-1BB/TNFRSF9/CD137 Antibody (158332) [Alexa Fluor® 594]
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4-1BB/TNFRSF9/CD137 Antibody (158332) [Alexa Fluor® 594]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clone
158332
Clonality
Monoclonal
Host
Rat
Conjugate
Alexa Fluor 594

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB937U-100UG
Alexa Fluor 405
FAB937V-100UG
Alexa Fluor 488
FAB937G-100UG
Alexa Fluor 532
FAB937X
Alexa Fluor 647
FAB937R-100UG
Alexa Fluor 700
FAB937N-100UG
Alexa Fluor 750
FAB937S-100UG
Allophycocyanin
FAB937A
Allophycocyanin/Cy7
FAB937APCCY7
Biotin
FAB937B
DyLight 350
FAB937D
DyLight 405
FAB937E
DyLight 488
FAB937K
DyLight 550
FAB937L
DyLight 594
FAB937M
DyLight 650
FAB937W
DyLight 680
FAB937Y
DyLight 755
FAB937Z
FITC
FAB937F
HRP
FAB937H
Janelia Fluor 525
FAB937JF525
Janelia Fluor 549
FAB937I
Janelia Fluor 646
FAB937J
Janelia Fluor 669
FAB937JF669
PE/Atto594
FAB937PEATT594
PE/Cy5.5
FAB937PECY55
PE/Cy7
FAB937PECY7
PerCP
FAB937C
Phycoerythrin
FAB937P
Unconjugated
MAB937
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB937
Carrier Free
FAB937P
Carrier Free
MAB937
Carrier Free
MAB937-SP
Carrier Free
FAB937V-100UG
Carrier Free
FAB937U-100UG
Carrier Free
FAB937S-100UG
Carrier Free
FAB937R-100UG
Carrier Free
FAB937N-100UG
Carrier Free
FAB937G-100UG
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4-1BB/TNFRSF9/CD137 Antibody (158332) [Alexa Fluor® 594] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse 4-1BB
Val24-Leu187
Accession # P20334
Specificity
Detects mouse 4-1BB in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) 4‑1BB, rhCD27, recombinant mouse (rm) CD27, rhCD30, rmCD30, rhCD40, rmCD40, rhDR3, rhDR6, rhEDAR, rmEDAR, rhFas, rmFas, rhGITR, rmGITR, rhHVEM, rhLTR beta , rhNGF R, rhOPG, rmOPG, rhRANK, rmRANK, rhTROY, rmTROY, rhTNF sRI, rhTNF sRII, or rmTNF sRII.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
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Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for 4-1BB/TNFRSF9/CD137 Antibody (158332) [Alexa Fluor® 594]

  • 4-1BB ligand receptor
  • 41BB
  • 4-1BB
  • CD137 antigen
  • CD137
  • CD137MGC2172
  • CDw137
  • FLJ43501
  • ILA
  • ILAhomolog of mouse 4-1BB
  • induced by lymphocyte activation (ILA)
  • interleukin-activated receptor, homolog of mouse Ly63
  • receptor protein 4-1BB
  • T cell antigen ILA
  • T-cell antigen 4-1BB homolog
  • T-cell antigen ILA
  • TNFRSF9
  • tumor necrosis factor receptor superfamily member 9
  • tumor necrosis factor receptor superfamily, member 9

Background

4-1BB, also known as CD137 and ILA (induced by lymphocyte activation), is a TNF receptor superfamily member and has been designated TNFRSF9. Mouse 4-1BB cDNA encodes a 256 amino acid (aa) residues type I transmembrane protein with a putative 23 aa signal peptide, a 164 aa extracellular domain, a 21 aa transmembrane domain and a 48 aa cytoplasmic region (1 - 3). A soluble 4-1BB is released from surfaces of cells expressing the transmembrane protein (4). Mouse 4‑1BB shares approximately 60% aa sequence identity with its human counterpart. 4-1BB is expressed on activated CD4+ and CD8+ T cells, thymocytes, and NK cells. It is also expressed on monocytes, neutrophils, DCs and eosinophils (5). The ligand for 4-1BB (4-1BBL), also named TNFSF9, belongs to the TNF ligand superfamily. 4-1BBL is predominantly expressed on activated antigen presenting cells (APCs) such as B cells, macrophages and dendritic cells (DCs). It is also expressed on most T and B lymphoma cell lines. In response to 4-1BBL binding, 4-1BB transduce a T cell costimulatory signal in both CD4+ and CD8+ T cells to promote survival and enhance proliferation, cytokine production and effector function. In vivo, the costimulatory activity of 4-1BB has been shown to be important in graft-vs-host disease and antiviral CTL responses. On dendritic cells, 4-1BB is a DC-activating molecules that enhances cytokine production and upregulates expression of B7-1 and B7‑2 costimulatory molecules, resulting in an improved ability to stimulate T cell responses (1 - 5).

  1. Goodwin, R.G. et al. (1993) Eur. J. Immunol. 23:2631.
  2. Alderson, M.R. et al. (1994) Eur. J. Immunol. 24:2219.
  3. Kwon, B.S. and S.M. Weissman (1989) Proc. Nat. Acad. Sci. USA 86:1963.
  4. Wilcox, R.A. et al. (2002) J. Immunol. 168:4262.
  5. Kwon, B. et al. (2002) TRENDS in Immunology 23:378.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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