14-3-3 gamma Antibody (HS23)

14-3-3 proteins are highly conserved and ubiquitously expressed proteins present as multigene families in most of the living organisms wherein they play a key role of bringing signal transduction to completion, and implicates in regulating several cellular processes including apoptosis, cell-cycle checkpoints and nutrient-sensing signaling pathways. 14-3-3 proteins have several isoforms which include -beta, -gamma, -epsilon, -sigma, -zeta, -tau, and -eta. 14-3-3 proteins can form homo- or heterodimers which interacts with a wide variety of proteins such as transcription factors, enzymes/kinases, cytoskeletal proteins, phosphatases, and other signaling molecules. 14-3-3 interactions with its targets occurs primarily via phospho-Ser/Thr motif, however, binding to divergent phospho-Ser/Thr motifs, as well as phosphorylation-independent interactions have been shown. 14-3-3 binding masks specific sequences of target proteins, thereby altering their localization, phosphorylation state, stability, and molecular interactions, and also induces target protein conformational changes which results in altered target protein function. Distinct temporal and spatial expression patterns of 14-3-3 isoforms have been observed in developmental and disease signaling which underlies their different functions despite sequence similarities.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Yeast.

We have publications tested in 3 applications: IHC-P, IP, WB.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NB100-407	Applications	Species
Pasquini M, Grosjean N, Hixson KK et al. Zng1 is a GTP-dependent zinc transferase needed for activation of methionine aminopeptidase Cell reports 2022-05-17 [PMID: 35584675] (WB, Yeast)	WB	Yeast
Sandebring-Matton A, Axenhus M, Bogdanovic N Et al. Microdissected Pyramidal Cell Proteomics of Alzheimer Brain Reveals Alterations in Creatine Kinase B-Type, 14-3-3-gamma, and Heat Shock Cognate 71 Frontiers in Aging Neuroscience 2021-11-19 [PMID: 34867272] (IHC-P, Human)	IHC-P	Human
Cao T, Jiang Y, Wang Z et al. MetAP2 inhibition increases energy expenditure through direct action on brown adipocytes J. Biol. Chem. 2019-05-02 [PMID: 31048375] (WB, Mouse)	WB	Mouse
Fujii K, Susanto TT, Saurabh S, Barna M. Decoding the Function of Expansion Segments in Ribosomes Mol. Cell 2018-12-20 [PMID: 30576652] (WB, Mouse)	WB	Mouse
Jonckheere V, Fijalkowska D, Van Damme P. Omics Assisted N-terminal Proteoform and Protein Expression Profiling On Methionine Aminopeptidase 1 (MetAP1) Deletion. Mol Cell Proteomics 2018-04-01 [PMID: 29317475]
Shim JS, Matsui Y, Bhat S et al. Effect of nitroxoline on angiogenesis and growth of human bladder cancer. J Natl Cancer Inst 2010-12-15 [PMID: 21088277] (WB, Mouse, Human)	WB	Mouse, Human
Hu, X et al. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A;103(48):18148-53. 2006-11-28 [PMID: 17114291]
Yang Q, Loureiro Z, Desai A et al. Regulation of lipolysis by 14-3-3 proteins on human adipocyte lipid droplets bioRxiv 2023-05-02 (WB, IP, Human)	WB, IP	Human
Kleppe R, Rosati S, Jorge-Finnigan A et al. Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3-gamma. Mol. Cell Proteomics. 2014-06-19 [PMID: 24947669] (WB, Human) Details: Native electrophoresis /immunodetection was performed on Tetrameric TH and dimeric 14-3-3 gamma complexes generated by mixing them in 1:3 subunit molar ratio (TH:14-3-3 gamma). 10 uM of purified TH (non-phosphorylated TH, TH-pS19 and TH-pS19pS40) was incubated with 30 uM 14-3-3 gamma for 5 min at room temperature and the samples were processed for WB using 14-3-3 gamma antibody at 1:1000 dilution.	WB	Human
Zhang F, Bhat S, Gabelli SB et al. Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem 2013-05-23 [PMID: 23634668] (WB, Human)	WB	Human
Bhat S, Shim JS, Zhang F et al. Substituted oxines inhibit endothelial cell proliferation and angiogenesis. Org Biomol Chem. 2012-04-21 [PMID: 22391578] (WB, Human)	WB	Human
Show All 11 Publications. Collapse Publications.

Array NB100-407

• 14-3-3 gamma Antibodies
• 14-3-3 gamma Lysate
• 14-3-3 gamma Proteins