UBE2I/Ubc9 Products

Description

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. Catalyzes the covalent attachment of ubiquitin-like protein SUMO-1 to other proteins. Forms a tight complex in association with two RAN GTPase interacting proteins, RANGAP1 and RANBP2. Interacts with E1A and E2A. Interacts with HIPK1 and HIPK2. Interacts with SIAH1 and PARP. Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus.

Bioinformatics

Entrez	22196 Mouse 25573 Rat 7329 Human
Uniprot	NM_003345 Human NM_194259 Human NP_003336 Human NP_003336. Human NP_003336.1 Human NP_919236 Human NP_919237 Human P63279 Human
Product By Gene ID	7329
Alternate Names	C358B7.1 EC 6.3.2 EC 6.3.2.- P18 p18 SUMO-1-protein ligase SUMO-protein ligase UBC9SUMO-conjugating enzyme UBC9 UBCE9 Ubiquitin carrier protein 9 Ubiquitin carrier protein I ubiquitin conjugating enzyme 9 Ubiquitin-conjugating enzyme E2 I ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9) ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) ubiquitin-conjugating enzyme UbcE2A ubiquitin-like protein SUMO-1 conjugating enzyme ubiquitin-protein ligase E2I Ubiquitin-protein ligase I