Species: Hu, Mu, Rt, Ch
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Dr
Applications: WB, IHC
Host: Sheep Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Rt
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Description
Smad 2 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, nine Smads have been identified and can be divided in 3 subgroups based on their structure and functions; pathway-restricted, common mediator and inhibitory Smad. Smad 2 and 3 serve as pathway-restricted Smads for the TGF-beta/activin signaling pathways (1-2). Smad 2 is phosphorylated by the TGF-beta type 1 receptor kinase on Ser 465 and Ser 467. Phosphorylation of both serines is essential for Smad 2-Smad4 heteromeric complex and dissociation of Smad 2 from the TGF-beta type 1 receptor (3). Once phosphorylated Smad2 translocate to the nucleus where it associates with DNA-binding proteins and forming a transcriptional complex (4). Unlike Smad 3 and 4, Smad 2 does not directly bind DNA (5).
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
4087 |
| Alternate Names |
- hMAD-2
- hSMAD2
- JV18
- JV18-1SMAD, mothers against DPP homolog 2 (Drosophila)
- MAD homolog 2
- Mad protein homolog
- Mad, mothers against decapentaplegic homolog 2
- MADH2MGC34440
- MADR2MGC22139
- Mad-related protein 2
- mother against DPP homolog 2
- mothers against decapentaplegic homolog 2
- Mothers against DPP homolog 2
- Sma- and Mad-related protein 2
- SMAD 2
- SMAD family member 2MAD, mothers against decapentaplegic homolog 2 (Drosophila)
- SMAD, mothers against DPP homolog 2
- Smad2
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