Ikaros/IKZF1 Products

Description

Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs)

Bioinformatics

Entrez	10320 Human 22778 Mouse
Uniprot	AAH18349.1 Human NP_006051.1 Human Q13422 Human
Product By Gene ID	10320
Alternate Names	DNA-binding protein Ikaros hIk-1 IK1LyF-1 Ikaros (zinc finger protein) IKAROS family zinc finger 1 (Ikaros) Ikaros family zinc finger protein 1 IKAROSLymphoid transcription factor LyF-1 LYF1PRO0758 zinc finger protein, subfamily 1A, 1 (Ikaros) ZNFN1A1CLL-associated antigen KW-6