ICAM-4 Products

Description

ICAM4 encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]

Bioinformatics

Entrez	3386 Human
Uniprot	NM_001039132 Human NM_001544 Human NP_001034221.1 Human
Product By Gene ID	3386
Alternate Names	CD242 antigen CD242 ICAM-4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) intercellular adhesion molecule 4 (LW blood group) intercellular adhesion molecule 4 intercellular adhesion molecule 4, Landsteiner-Wiener blood group Landsteiner-Wiener blood group antigen a Landsteiner-Wiener blood group glycoprotein Landsteiner-Wiener blood group LWLW blood group protein

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Chromatin reader domains of DNMT-targeting protein, UHRF1, are responsible for cancerous DNA hypermethylation By Jamshed Arslan, Pharm. D., PhD. DNA methylation represses transcription of many genes, including tumor suppressor genes. A protein called UHRF1 recruits DNA methyltransferases (DNMTs) to establish and maintain DNA...    Read more.

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